ArticleMolecular and cellular biology1999
Definition of transcriptional pause elements in fission yeast.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Polymerase pausing induced by sequence-specific RNA-binding protein drives heterochromatin assembly.Genes & development · 2018Article
- The Nrd1-like protein Seb1 coordinates cotranscriptional 3' end processing and polyadenylation site selection.Genes & development · 2016Article
- An antisense RNA-mediated mechanism eliminates a meiosis-specific copper-regulated transcript in mitotic cells.The Journal of biological chemistry · 2015Article
- Repression of meiotic genes by antisense transcription and by Fkh2 transcription factor in Schizosaccharomyces pombe.PloS one · 2012Article
- Autoregulation of convergent RNAi genes in fission yeast.Genes & development · 2011Article
- Torpedo nuclease Rat1 is insufficient to terminate RNA polymerase II in vitro.The Journal of biological chemistry · 2009Article
- A complex gene regulatory mechanism that operates at the nexus of multiple RNA processing decisions.Nature structural & molecular biology · 2009Article
- Strong polyadenylation and weak pausing combine to cause efficient termination of transcription in the human Ggamma-globin gene.Molecular and cellular biology · 2005Article
- In vivo evidence that defects in the transcriptional elongation factors RPB2, TFIIS, and SPT5 enhance upstream poly(A) site utilization.Molecular and cellular biology · 2003Article
- In vitro activity of the baculovirus late expression factor LEF-5.Journal of virology · 2002Article
- An RNA polymerase pause site is associated with the immunoglobulin mus poly(A) site.Molecular and cellular biology · 2002Article
- Premature termination of RNA polymerase II mediated transcription of a seed protein gene in Schizosaccharomyces pombe.Nucleic acids research · 2002Article
- Glucose-inducible expression of rrg1+ in Schizosaccharomyces pombe: post-transcriptional regulation of mRNA stability mediated by the downstream region of the poly(A) site.Nucleic acids research · 2002Article
- Degeneracy and complexity in biological systems.Proceedings of the National Academy of Sciences of the United States of America · 2001Review
- Mechanism of poly(A) signal transduction to RNA polymerase II in vitro.Molecular and cellular biology · 2001Article
- The stress-activated MAP kinase Sty1/Spc1 and a 3'-regulatory element mediate UV-induced expression of the uvi15(+) gene at the post-transcriptional level.Nucleic acids research · 2000Article
- Transcriptional termination and coupled polyadenylation in vitro.The EMBO journal · 2000Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Downstream elements (DSEs) with transcriptional pausing activity play an important role in transcription termination of RNA polymerase II. We have defined two such DSEs in Schizosaccharomyces pombe, one for the ura4 gene and a new one in the 3'-end region of the nmt2 gene. Although these DSEs do not have sequence homology, both are orientation specific and are composed of multiple and redundant sequence elements that work together to achieve full pausing activity. Previous studies on the nmt1 and nmt2 genes revealed that transcription extends several kilobases past the genes' poly(A) sites. We show that the insertion of either DSE immediately downstream of the nmt1 poly(A) site induces more immediate termination. nmt2 termination efficiency can be increased by moving the DSE closer to the poly(A) site. These results suggest that DSEs may be a common feature in yeast genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.