ArticleMolecular and cellular biology1999
Selective interaction of vitamin D receptor with transcriptional coactivators by a vitamin D analog.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 199 citations in OpenAlex.
- Maxacalcitol (22-Oxacalcitriol (OCT)) Retards Progression of Left Ventricular Hypertrophy with Renal Dysfunction Through Inhibition of Calcineurin-NFAT Activity.Cardiovascular drugs and therapy · 2021Trial
- Vitamin D as an Immuno-Endocrine Modulator: Discovering Its Role in Autoimmune Disorders and Host Defense Mechanisms.Journal of clinical medicine · 2026Review
- The Role of Vitamin D in Neuropathic Pain: Biological Mechanisms and Clinical Relevance.International journal of molecular sciences · 2026Review
- Vitamin D Receptor Regulates the Expression of the Grainyhead-Like 1 Gene.International journal of molecular sciences · 2024Article
- The vitamin D receptor TaqI TT genotype is associated with type 1 diabetes in the Black South African population.Journal of nutritional science · 2024Observational
- Anti-Inflammatory Effects of 1,25(OH)2D/Calcitriol in T Cell Immunity: Does Sex Make a Difference?International journal of molecular sciences · 2022Article
- The role of vitamin D in autoimmune diseases: could sex make the difference?Biology of sex differences · 2021Review
- The Vitamin D Receptor in Osteoblast-Lineage Cells Is Essential for the Proresorptive Activity of 1α,25(OH)2D3 In Vivo.Endocrinology · 2020Article
- Dexmedetomidine exerts neuroprotective effects during high glucose-induced neural injury by inhibiting miR-125b.Bioscience reports · 2020Article
- Article
- Excess 25-hydroxyvitamin D3 exacerbates tubulointerstitial injury in mice by modulating macrophage phenotype.Kidney international · 2015Article
- Vitamin D metabolism, mechanism of action, and clinical applications.Chemistry & biology · 2014Review
- Vitamin D deficiency is associated with increased left ventricular mass and diastolic dysfunction in children with chronic kidney disease.Pediatric cardiology · 2013Article
- Article
- The enhanced hypercalcemic response to 20-epi-1,25-dihydroxyvitamin D3 results from a selective and prolonged induction of intestinal calcium-regulating genes.Endocrinology · 2009Article
- Drosophila TRAP230/240 are essential coactivators for Atonal in retinal neurogenesis.Developmental biology · 2007Article
- Review
- Review
- Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin D receptor modulators.The Journal of clinical investigation · 2006Article
- Transrepression by a liganded nuclear receptor via a bHLH activator through co-regulator switching.The EMBO journal · 2004Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nuclear vitamin D receptor (VDR) is a member of a nuclear receptor superfamily and acts as a ligand-dependent transcription factor. A family of cotranscriptional activators (SRC-1, TIF2, and AIB-1) interacts with and activates the transactivation function of nuclear receptors in a ligand-dependent way. We examined interaction of VDR with these coactivators that was induced by several vitamin D analogs, since they exert differential subsets of the biological action of vitamin D through unknown mechanisms. Unlike other vitamin D analogs tested, OCT (22-oxa-1alpha,25-dihydroxyvitamin D3) induced interaction of VDR with TIF2 but not with SRC-1 or AIB-1. Consistent with these interactions, only TIF2 was able to potentiate the transactivation function of VDR bound to OCT. Thus, the present findings suggest that the structure of VDR is altered in a vitamin D analog-specific way, resulting in selective interactions of VDR with coactivators. Such selective interaction of coactivators with VDR may specify the array of biological actions of a vitamin D analog like OCT, possibly through activating a particular set of target gene promoters.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.