ReviewAdvances in veterinary medicine1999
Mechanistic bases for adverse vaccine reactions and vaccine failures.
Review in Advances in veterinary medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Safety and immunogenicity of an intranasal vaccine against pneumonic mannheimiosis of sheep and goats following field vaccination.Open veterinary journal · 2026Article
- Increased ruminoreticular temperature after simultaneous lumpy skin disease and foot-and-mouth disease vaccination in Hanwoo (Journal of veterinary science · 2026Article
- Article
- Pig nasal and rectal microbiotas are involved in the antibody response to Glaesserella parasuis.Scientific reports · 2025Article
- Immunization of cattle with aParasitology · 2024Article
- Supplementing young cattle with a rumen-protected grape extract around vaccination increases humoral response and antioxidant defenses.Veterinary and animal science · 2022Article
- Investigation of protective level of rabies antibodies in vaccinated dogs in Chennai, India.Veterinary record open · 2021Article
- Adverse events and preventive measures related to COVID-19 vaccines.Clinical and experimental emergency medicine · 2021Article
- Anaphylaxis after rabies vaccination for dogs in Japan.The Journal of veterinary medical science · 2021Article
- Replication of Small Ruminant Lentiviruses in Aluminum Hydroxide-Induced Granulomas in Sheep: a Potential New Factor for Viral Dissemination.Journal of virology · 2020Article
- Vaccination Management of Beef Cattle: Delayed Vaccination and Endotoxin Stacking.The Veterinary clinics of North America. Food animal practice · 2019Review
- Systems Immunology Characterization of Novel Vaccine Formulations forFrontiers in immunology · 2019Article
- On-farm storage of livestock vaccines may be a risk to vaccine efficacy: a study of the performance of on-farm refrigerators to maintain the correct storage temperature.BMC veterinary research · 2018Article
- Effects of body weight on antibody titers against canine parvovirus type 2, canine distemper virus, and canine adenovirus type 1 in vaccinated domestic adult dogs.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2012Article
- Large-scale survey of adverse reactions to canine non-rabies combined vaccines in Japan.Veterinary immunology and immunopathology · 2012Article
- Accidental introduction of viruses into companion animals by commercial vaccines.The Veterinary clinics of North America. Small animal practice · 2008Review
- Use of adenoviral vectors as veterinary vaccines.Gene therapy · 2005Review
- IgE reactivity to vaccine components in dogs that developed immediate-type allergic reactions after vaccination.Veterinary immunology and immunopathology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mild local and systemic reactions to vaccines are to be expected as a natural consequence of vigorously stimulating the immune system. Dramatic adverse reactions to vaccines are occasionally due to mistakes during the production or handling of vaccines. More often, they are due to not following label instructions, particularly the restriction to only use vaccines in healthy animals. It is important to publish well-documented instances of adverse vaccine reactions so that producers and users of vaccines can all learn from the experience and avoid similar problems. Vaccine failure to protect from disease is usually due to problems with either client education or compliance with good animal management practices. It is important for clients to understand the proper timing and method of vaccine administration, what to realistically expect for vaccine efficacy, and the importance of minimizing immunosuppressive factors and exposure to high doses of infectious agents in vaccinated animals. Veterinary vaccines have produced dramatic benefits in terms of animal health, human health, and efficiency of food production. Advances in research and the accumulating experience with vaccines are leading to safer and more effective vaccines. Proper usage of vaccines and adherence to good management practices will continue to be essential to achieve maximal vaccine safety and efficacy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.