ArticleBritish journal of cancer1999
Allelotype influence at glutathione S-transferase M1 locus on breast cancer susceptibility.
Article in British journal of cancer, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 53 citations in OpenAlex.
- Investigating the Role of Glutathione S- Transferase Genes, Histopathological and Molecular Subtypes, Gene-Gene Interaction and Its Susceptibility to Breast Carcinoma in Ethnic North- Indian Population.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Germline copy number variations are associated with breast cancer risk and prognosis.Scientific reports · 2017Article
- Prospective Case-Control Study to Evaluate the Role of Glutathione S Transferases (GSTT1 and GSTM1) Gene Deletion in Breast Carcinoma and Its Prognostic Significance.The Indian journal of surgery · 2015Article
- Interaction between glutathione-S-transferase polymorphisms, smoking habit, and HPV infection in cervical cancer risk.Journal of cancer research and clinical oncology · 2010Article
- Genetic polymorphisms in oestrogen metabolic pathway and breast cancer: a positive association with combined CYP/GST genotypes.Clinical and experimental medicine · 2008Article
- Glutathione S-transferase M1 and P1 polymorphisms and risk of breast cancer and fibrocystic breast conditions in Chinese women.Breast cancer research and treatment · 2008Article
- Interleukin-10 polymorphisms, cancer susceptibility and prognosis.Familial cancer · 2006Review
- Glutathione S-transferase M1 and T1 genetic polymorphisms, alcohol consumption and breast cancer risk.British journal of cancer · 2003Article
- Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility.Journal of medical genetics · 2002Review
- Analysis association between mitochondrial genome instability and xenobiotic metabolizing genes in human breast cancer.Molecular medicine (Cambridge, Mass.)Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The influence of polymorphisms of the glutathione S-transferase gene GSTM1 in breast cancer susceptibility has been assessed in this study. Previous studies correlated the absence of the GSTM1 protein with an increased risk of developing some cancers, especially lung or bladder cancers, in heavy smokers. In this study, we determined GSTM1 polymorphisms in a population of 437 female controls from the west of France and 361 community breast cancer patients. Three distinct alleles of this gene exist: GSTM1*A, GSTM1*B and GSTM1*0 (deleted allele). Null subjects (GSTM1 null) are homozygous for this deletion. The comparative analysis of GSTM1 allelotypes in our two populations did not demonstrate a statistically significant difference in distribution (P = 0.22), although the null genotype was more frequent in cancer patients. However, breast cancer risk was increased in null subjects > or = 50 years of age compared with non-null subjects [odds ratio = 1.99 (1.19-3.32), P = 0.009], but not in null subjects < 50 years of age compared with non-null subjects (P = 0.86). Our results suggest that the GSTM1 null genotype may play a role in post-menopausal breast cancer development. They also point to a putative protective role of the A allele in the older female control group, especially in hemizygous subjects [odds ratio = 0.42 (0.23-0.77), P = 0.03].
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