ArticleBritish journal of cancer1999
Creatine and cyclocreatine treatment of human colon adenocarcinoma xenografts: 31P and 1H magnetic resonance spectroscopic studies.
Article in British journal of cancer, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 55 citations in OpenAlex.
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- Targeting Creatine and Creatine Kinase in Cancer: Exploring Potential Therapeutic Strategies.Current drug targets · 2025Review
- It Is Not Just About Storing Energy: The Multifaceted Role of Creatine Metabolism on Cancer Biology and Immunology.International journal of molecular sciences · 2024Review
- 17β-Estradiol Effects in Skeletal Muscle: ADiagnostics (Basel, Switzerland) · 2024Article
- Impact of Opioids on Cellular Metabolism: Implications for Metabolic Pathways Involved in Cancer.Pharmaceutics · 2023Review
- Creatine kinase brain-type regulates BCAR1 phosphorylation to facilitate DNA damage repair.iScience · 2023Article
- Creatine in T Cell Antitumor Immunity and Cancer Immunotherapy.Nutrients · 2021Review
- Creatine metabolism: energy homeostasis, immunity and cancer biology.Nature reviews. Endocrinology · 2020Review
- Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health.Amino acids · 2020Review
- Creatine uptake regulates CD8 T cell antitumor immunity.The Journal of experimental medicine · 2019Article
- Article
- Dietary Creatine as a Possible Novel Treatment for Crohn's Ileitis.ACG case reports journal · 2016Article
- Nanofabrication of methylglyoxal with chitosan biopolymer: a potential tool for enhancement of its anticancer effect.International journal of nanomedicine · 2015Article
- An overview of amines as nutritional supplements to counteract cancer cachexia.Journal of cachexia, sarcopenia and muscle · 2014Article
- High-field small animal magnetic resonance oncology studies.Physics in medicine and biology · 2014Review
- Phosphocreatine interacts with phospholipids, affects membrane properties and exerts membrane-protective effects.PloS one · 2012Article
- Oral creatine supplementation and skeletal muscle metabolism in physical exercise.Sports medicine (Auckland, N.Z.) · 2002Review
- Changes in vascularization of human breast cancer xenografts responding to antiestrogen therapy.Neoplasia (New York, N.Y.) · 1999Article
- MRI of transgene expression: correlation to therapeutic gene expression.Neoplasia (New York, N.Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Creatine (Cr) and cyclocreatine (cyCr) have been shown to inhibit the growth of a variety of human and murine tumours. The purpose of this study was to evaluate the anti-tumour effect of these molecules in relation to drug accumulation, energy metabolism, tumour water accumulation and toxicity. Nude mice carrying a human colon adenocarcinoma (LS174T) with a creatine kinase (CK) activity of 2.12 units mg(-1) protein were fed Cr (2.5% or 5%) or cyCr (0.025%, 0.1% or 0.5%) for 2 weeks and compared with controls fed standard diet. Cr concentrations of 2.5% and 5% significantly inhibited tumour growth, as did 0.1% and 0.5% cyCr. In vivo 31P magnetic resonance spectroscopy (MRS) after 2 weeks of treatment showed an increase in [phosphocreatine (PCr)+phosphocyclocreatine (PcyCr)]/nucleoside triphosphate (NTP) with increasing concentrations of dietary Cr and cyCr, without changes in absolute NTP contents. The antiproliferative effect of the substrates of CK was not related to energy deficiency but was associated with acidosis. Intratumoral substrate concentrations (measured by 1H-MRS) of 4.8 micromol g(-1) wet weight Cr (mice fed 2.5% Cr) and 6.2 micromol g(-1) cyCr (mice fed 0.1% cyCr) induced a similar decrease in growth rate, indicating that both substrates were equally potent in tumour growth inhibition. The best correlant of growth inhibition was the total Cr or (cyCr+Cr) concentrations in the tissue. In vivo, these agents did not induce excessive water accumulation and had no systemic effects on the mice (weight loss, hypoglycaemia) that may have caused growth inhibition.
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Registered trials
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