ArticleGenes & development1999
Mechanisms of developmental control of transcription in the murine alpha- and beta-globin loci.
Article in Genes & development, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 145 citations in OpenAlex.
- A Refined Single Cell Landscape of Haematopoiesis in the Mouse Foetal Liver.Journal of developmental biology · 2023Article
- Chromatin Conformation in Development and Disease.Frontiers in cell and developmental biology · 2021Review
- An intergenic non-coding RNA promoter required for histone modifications in the human β-globin chromatin domain.PloS one · 2019Article
- MAPK p38alpha Kinase Influences Haematopoiesis in Embryonic Stem Cells.Stem cells international · 2019Article
- HIC2 regulates isoform switching during maturation of the cardiovascular system.Journal of molecular and cellular cardiology · 2018Article
- Mouse Models of Erythropoiesis and Associated Diseases.Methods in molecular biology (Clifton, N.J.) · 2018Review
- Article
- Enhancer Regulation of Transcriptional Bursting Parameters Revealed by Forced Chromatin Looping.Molecular cell · 2016Article
- Characterization of the enhancer element of the Danio rerio minor globin gene locus.Histochemistry and cell biology · 2016Article
- Predicting the three-dimensional folding of cis-regulatory regions in mammalian genomes using bioinformatic data and polymer models.Genome biology · 2016Article
- Atypical PKC-iota Controls Stem Cell Expansion via Regulation of the Notch Pathway.Stem cell reports · 2015Article
- β-thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies.Haematologica · 2015Review
- Biased allelic expression in human primary fibroblast single cells.American journal of human genetics · 2015Article
- The modern primitives: applying new technological approaches to explore the biology of the earliest red blood cells.ISRN hematology · 2013Review
- Microscopy ambient ionization top-down mass spectrometry reveals developmental patterning.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing.Molecular and cellular biology · 2013Article
- Stat and interferon genes identified by network analysis differentially regulate primitive and definitive erythropoiesis.BMC systems biology · 2013Article
- Article
- A dual reporter mouse model of the human β-globin locus: applications and limitations.PloS one · 2012Article
- Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6.BMC developmental biology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have characterized mRNA expression and transcription of the mouse alpha- and beta-globin loci during development. S1 nuclease and primary transcript in situ hybridization analyses demonstrate that all seven murine globin genes (zeta, alpha1, alpha2, epsilony, betaH1, betamaj, and betamin) are transcribed during primitive erythropoiesis, however transcription of the zeta, epsilony, and betaH1 genes is restricted to the primitive erythroid lineage. Transcription of the betamaj and betamin genes in primitive cells is EKLF-dependent demonstrating EKLF activity in embryonic red cells. Novel kinetic analyses suggest that multigene expression in the beta locus occurs via alternating single-gene transcription whereas coinitiation cannot be ruled out in the alpha locus. Transcriptional activation of the individual murine beta genes in primitive cells correlates inversely with their distance from the locus control region, in contrast with the human beta locus in which the adult genes are only activated in definitive erythroid cells. The results suggest that the multigene expression mechanism of alternating transcription is evolutionarily conserved between mouse and human beta globin loci but that the timing of activation of the adult genes is altered, indicating important fundamental differences in globin gene switching.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.