ArticleThe Journal of comparative neurology1999
Dense-cored vesicles, smooth endoplasmic reticulum, and mitochondria are closely associated with non-specialized parts of plasma membrane of nerve terminals: implications for exocytosis and calcium buffering by intraterminal organelles.
Article in The Journal of comparative neurology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
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- Mitochondrial protein S-nitrosation protects against ischemia reperfusion-induced denervation at neuromuscular junction in skeletal muscle.Free radical biology & medicine · 2018Article
- Peptide Cotransmitters as Dynamic, Intrinsic Modulators of Network Activity.Frontiers in neural circuits · 2018Review
- CaJournal of chemical neuroanatomy · 2017Article
- Structure activity relationship of synaptic and junctional neurotransmission.Autonomic neuroscience : basic & clinical · 2013Review
- Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease.Cell death & disease · 2013Article
- A model of cellular cardiac-neural coupling that captures the sympathetic control of sinoatrial node excitability in normotensive and hypertensive rats.Biophysical journal · 2011Article
- Molecular microdomains in a sensory terminal, the vestibular calyx ending.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Neuropeptide signaling near and far: how localized and timed is the action of neuropeptides in brain circuits?Invertebrate neuroscience : IN · 2009Review
- MAM: more than just a housekeeper.Trends in cell biology · 2009Review
- Use-dependent control of presynaptic calcium signalling at central synapses.Journal of anatomy · 2007Review
- The contribution of intracellular calcium stores to mEPSCs recorded in layer II neurones of rat barrel cortex.The Journal of physiology · 2002Article
- Membrane proximal lysosomes are the major vesicles responsible for calcium-dependent exocytosis in nonsecretory cells.The Journal of cell biology · 2002Article
- Presynaptic mitochondrial calcium sequestration influences transmission at mammalian central synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Alterations in exocytosis induced by neuronal Ca2+ sensor-1 in bovine chromaffin cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Differential regulation of transmitter release by presynaptic and glial Ca2+ internal stores at the neuromuscular synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- A four-compartment model for Ca2+ dynamics: an interpretation of Ca2+ decay after repetitive firing of intact nerve terminals.Journal of computational neuroscienceArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
To determine whether there are anatomical correlates for intraterminal Ca2+ stores to regulate exocytosis of dense-cored vesicles (DCVs) and whether these stores can modulate exocytosis of synaptic vesicles, we studied the spatial distributions of DCVs, smooth endoplasmic reticulum (SER), and mitochondria in 19 serially reconstructed nerve terminals in bullfrog sympathetic ganglia. On average, each bouton had three active zones, 214 DCVs, 26 SER fragments (SERFs), and eight mitochondria. DCVs, SERFs and mitochondria were located, on average, 690, 624, and 526 nm, respectively, away from active zones. Virtually no DCVs were within "docking" (i.e., < or = 50 nm) distances of the active zones. Thus, it is unlikely that DCV exocytosis occurs at active zones via mechanisms similar to those for exocytosis of synaptic vesicles. Because there were virtually no SERFs or mitochondria within 50 nm of any active zone, Ca2+ modulation by these organelles is unlikely to affect ACh release evoked by a single action potential. In contrast, 30% of DCVs and 40% of SERFs were located within 50 nm of the nonspecialized regions of the plasma membrane. Because each bouton had at least one SERF within 50 nm of the plasma membrane and most of these SERFs had DCVs, but not mitochondria, near them, it is possible for Ca2+ release from the SER to provide the Ca2+ necessary for DCV exocytosis. The fact that 60% of the mitochondria had some part within 50 nm of the plasma membrane means that it is possible for mitochondrial Ca2+ buffering to affect DCV exocytosis.
Indexed as
Identifiers
9886037PMC12058274W2020008894What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.