ArticleThe Journal of physiology1999
Activity of aortic chemoreceptors in the anaesthetized rat.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 71 citations in OpenAlex.
- Intra-carotid body inter-cellular communication.Journal of the Royal Society of New Zealand · 2023Review
- A Novel Organ-Specific Approach to Selectively Target Sensory Afferents Innervating the Aortic Arch.Frontiers in physiology · 2022Article
- Laterality Influences Central Integration of Baroreceptor Afferent Input in Male and Female Sprague Dawley Rats.Frontiers in physiology · 2020Article
- Lessons from single-cell transcriptome analysis of oxygen-sensing cells.Cell and tissue research · 2018Review
- Ventilatory and Autonomic Regulation in Sleep Apnea Syndrome: A Potential Protective Role for Erythropoietin?Frontiers in physiology · 2018Article
- Enhanced Firing in NTS Induced by Short-Term Sustained Hypoxia Is Modulated by Glia-Neuron Interaction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Nitric oxide stimulates glutamatergic synaptic inputs to baroreceptor neurons through potentiation of Cav2.2-mediated Ca(2+) currents.Neuroscience letters · 2014Article
- Autocrine/paracrine modulation of baroreceptor activity after antidromic stimulation of aortic depressor nerve in vivo.Autonomic neuroscience : basic & clinical · 2014Article
- Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat.The Journal of physiology · 2012Article
- Activation of NTS A(1) adenosine receptors inhibits regional sympathetic responses evoked by activation of cardiopulmonary chemoreflex.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- Effects of chemostimuli on [Ca2+]i responses of rat aortic body type I cells and endogenous local neurons: comparison with carotid body cells.The Journal of physiology · 2012Article
- Carotid chemoafferent activity is not necessary for all phrenic long-term facilitation following acute intermittent hypoxia.Respiratory physiology & neurobiology · 2011Article
- The effect of pro-inflammatory cytokines on the discharge rate of vagal nerve paraganglia in the rat.Respiratory physiology & neurobiology · 2010Article
- Effects of baroreceptor activation on respiratory variability in rat.Respiratory physiology & neurobiology · 2009Article
- Frequency response of renal sympathetic nervous activity to aortic depressor nerve stimulation in the anaesthetized rat.The Journal of physiology · 2001Article
- Responses of aortic depressor nerve-evoked neurones in rat nucleus of the solitary tract to changes in blood pressure.The Journal of physiology · 2000Article
- Ventilatory and central neurochemical reorganisation of O2 chemoreflex after carotid sinus nerve transection in rat.The Journal of physiology · 2000Article
- Activity of aortic chemoreceptors in the anaesthetized rat.The Journal of physiology · 1999Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
1. It has been widely accepted that the rat aortic depressor nerve contains only baroreceptors. However, the experiments which have provided these negative data have employed whole aortic nerve recording. In the present study, the technical difficulties associated with recording single fibres in vivo, from the rat aortic nerve (diameter 25-50 microm), have been surmounted using a small tip, glass suction electrode technique. 2. Upon switching from normocapnic hyperoxia to hypercapnic hypoxia, irregularly firing units (n = 13) appeared and these were significantly excited by intravenous injections of sodium cyanide (20 microg) but not by rises in arterial blood pressure induced by methoxamine (an alpha1-adrenoreceptor agonist; 10 microg). Inhalation of 100 % oxygen rapidly and reversibly silenced, or profoundly reduced, ongoing activity. 3. Intravenous injection of phenylbiguanide (PBG; a 5-HT3 receptor agonist; 8 microg) strongly stimulated the chemoreceptors and was followed by a period of chemodepression (3-21 s). In contrast none of the single fibre baroreceptors recorded (n = 15) were excited by PBG but all significantly increased their discharge in response to the increases in arterial blood pressure associated with methoxamine and cyanide. Both the excitatory and inhibitory effects of PBG on the chemoreceptor fibres were abolished by ondansetron (a 5-HT3 receptor antagonist: 1 mg kg-1 i.v.; n = 5 animals) whilst the chemoexcitatory action of cyanide was preserved. 4. It is concluded that there are chemoreceptor afferents contained in the aortic nerve of the Sprague-Dawley rat. The 5-HT3 receptor appears not to be a pre-requisite for aortic body chemoexcitation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.