ArticleThe Journal of physiology1999
Presynaptic effects of muscarine on ACh release at the frog neuromuscular junction.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 87 citations in OpenAlex.
- Effect of respiratory acid-base balance on rocuronium-induced neuromuscular blockade and sugammadex-induced reversal in rat phrenic nerve hemidiaphragm.Anesthesia and pain medicine · 2026Article
- Activity-dependent muscarinic signalling regulates presynaptic PKC pathway and neurotransmission machinery at the neuromuscular junction.Cell communication and signaling : CCS · 2025Article
- Molecular Adaptations of BDNF/NT-4 Neurotrophic and Muscarinic Pathways in Ageing Neuromuscular Synapses.International journal of molecular sciences · 2024Article
- Purinergic Tuning of the Tripartite Neuromuscular Synapse.Molecular neurobiology · 2023Review
- Muscarinic Receptors in Developmental Axonal Competition at the Neuromuscular Junction.Molecular neurobiology · 2023Article
- Presynaptic Acetylcholine Receptors Modulate the Time Course of Action Potential-Evoked Acetylcholine Quanta Secretion at Neuromuscular Junctions.Biomedicines · 2022Review
- Effects of different sugammadex doses on the train of four ratio recovery progression during rocuronium induced neuromuscular blockade in the rat phrenic nerve hemidiaphragm.Korean journal of anesthesiology · 2020Article
- Review
- Effects of neuromuscular presynaptic muscarinic MClinical and experimental pharmacology & physiology · 2018Article
- Effects of adenosine receptor agonist on the rocuroniuminduced neuromuscular block and sugammadex-induced recovery.Korean journal of anesthesiology · 2018Article
- Factors that affect the onset of action of non-depolarizing neuromuscular blocking agents.Korean journal of anesthesiology · 2017Review
- Effects of presynaptic muscarinic cholinoreceptor blockade on neuromuscular transmission as assessed by the train-of-four and the tetanic fade response to rocuronium.Clinical and experimental pharmacology & physiology · 2017Article
- Presynaptic Membrane Receptors Modulate ACh Release, Axonal Competition and Synapse Elimination during Neuromuscular Junction Development.Frontiers in molecular neuroscience · 2017Review
- Acetylcholine-Induced Inhibition of Presynaptic Calcium Signals and Transmitter Release in the Frog Neuromuscular Junction.Frontiers in physiology · 2016Article
- The novel protein kinase C epsilon isoform modulates acetylcholine release in the rat neuromuscular junction.Molecular brain · 2015Article
- Muscarinic inhibition of nicotinic transmission in rat sympathetic neurons and adrenal chromaffin cells.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- α-Conotoxin M1 (CTx) blocks αδ binding sites of adult nicotinic receptors while ACh binding at αε sites elicits only small and short quantal synaptic currents.Physiological reports · 2014Article
- A novel fast mechanism for GPCR-mediated signal transduction--control of neurotransmitter release.The Journal of cell biology · 2011Article
- The interaction between tropomyosin-related kinase B receptors and presynaptic muscarinic receptors modulates transmitter release in adult rodent motor nerve terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Control of neurotransmitter release: From Ca2+ to voltage dependent G-protein coupled receptors.Pflugers Archiv : European journal of physiology · 2010Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Presynaptic effects of muscarine on neurotransmitter release were studied at the frog neuromuscular junction, using focal depolarization of the presynaptic terminal to different levels. 2. Muscarine (10 microM) had a dual effect on ACh release: concomitant inhibition and enhancement of release at the same patch of presynaptic membrane. 3. These two effects were maximal at low depolarizing pulses and diminished as depolarization increased. 4. At low depolarizing pulses, atropine (1 microM) enhanced release, suggesting that ACh in the synaptic cleft causes a net tonic inhibition of ACh release. 5. In the presence of the M2 antagonist methoctramine (1 microM), muscarine (10 microM) enhanced ACh release. 6. In the presence of the M1 antagonist pirenzepine (10 microM), muscarine (10 microM) produced stronger inhibition. 7. These results show that the M2 receptor is responsible for inhibition of ACh release, while the M1 receptor is responsible for its enhancement. 8. The inhibitory effect of muscarine did not depend on extracellular [Ca2+]. Enhancement of release was abolished at low extracellular [Ca2+]. 9. The muscarine inhibitory effect was not associated with a reduction of Ca2+ current, while release enhancement was associated with an increase of Ca2+ current.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.