ArticleThe Journal of physiology1999
Axonal expression of sodium channels in rat spinal neurones during postnatal development.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Intrinsic burst-firing in lamina I spinoparabrachial neurons during adolescence.Neuroscience letters · 2021Article
- Comparison of NMDA and AMPA Channel Expression and Function between Embryonic and Adult Neurons Utilizing Microelectrode Array Systems.ACS biomaterials science & engineering · 2017Article
- Somato-dendritic decoupling as a novel mechanism for protracted cortical maturation.BMC biology · 2016Article
- Properties of sodium currents in neonatal and young adult mouse superficial dorsal horn neurons.Molecular pain · 2015Article
- The microtubule-based cytoskeleton is a component of a mechanical signaling pathway in fly campaniform receptors.Biophysical journal · 2014Article
- Transcriptional expression of voltage-gated Na⁺ and voltage-independent K⁺ channels in the developing rat superficial dorsal horn.Neuroscience · 2013Article
- Article
- Brain-derived neurotrophic factor drives the changes in excitatory synaptic transmission in the rat superficial dorsal horn that follow sciatic nerve injury.The Journal of physiology · 2009Article
- Upregulation of persistent and ramp sodium current in dorsal horn neurons after spinal cord injury.Experimental brain research · 2006Article
- Mechanism of spike frequency adaptation in substantia gelatinosa neurones of rat.The Journal of physiology · 2004Article
- Excitability of the soma in central nervous system neurons.Biophysical journal · 2000Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Postnatal expression of Na+ channels and development of somatic excitability were studied in dorsal horn neurones of rat using patch-clamp recordings from spinal cord slices in combination with the 'entire soma isolation' method. 2. The amplitude of Na+ current in the intact neurone in the slice increased with postnatal development (days 0-39) with a mean rate of 83 pA day-1. 3. The Na+ current in the neuronal soma did not increase with age and the soma, separated from the axon, was not able to fire spikes at any stage of development studied. 4. It is concluded that the postnatal development of the spinal dorsal horn neurone is accompanied by intensive expression of Na+ channels in the axonal but not somatic membrane. The estimated minimum density of Na+ channels in the axon initial segment is approximately 160 channels microm-2.
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