ArticleThe Biochemical journal1999
Expression and subcellular localization of the ryanodine receptor in rat pancreatic acinar cells.
Article in The Biochemical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 74 citations in OpenAlex.
- Modelling mechanism of calcium oscillations in pancreatic acinar cells.Journal of bioenergetics and biomembranes · 2014Article
- The ryanodine receptor is expressed in human pancreatic acinar cells and contributes to acinar cell injury.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Modelling the transition from simple to complex Ca²⁺ oscillations in pancreatic acinar cells.Journal of biosciences · 2014Article
- Cluster of differentiation 38 (CD38) mediates bile acid-induced acinar cell injury and pancreatitis through cyclic ADP-ribose and intracellular calcium release.The Journal of biological chemistry · 2013Article
- Calcium signaling in the liver.Comprehensive Physiology · 2013Review
- Ryanodine receptors contribute to bile acid-induced pathological calcium signaling and pancreatitis in mice.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Low extracellular pH induces damage in the pancreatic acinar cell by enhancing calcium signaling.The Journal of biological chemistry · 2011Article
- Inhibitors of Bcl-2 protein family deplete ER Ca2+ stores in pancreatic acinar cells.Pflugers Archiv : European journal of physiology · 2010Article
- Dantrolene mitigates caerulein-induced pancreatitis in vivo in mice.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- Cyclic AMP accelerates calcium waves in pancreatic acinar cells.American journal of physiology. Gastrointestinal and liver physiology · 2008Article
- Effects of FK506 on ca release channels (review).Perspectives in medicinal chemistry · 2008Article
- Lipid rafts establish calcium waves in hepatocytes.Gastroenterology · 2007Article
- Calcium signaling in cholangiocytes.World journal of gastroenterology · 2006Review
- The ryanodine receptor mediates early zymogen activation in pancreatitis.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- A model of calcium waves in pancreatic and parotid acinar cells.Biophysical journal · 2003Article
- Nuclear and cytosolic calcium are regulated independently.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Is all of the endoplasmic reticulum created equal? The effects of the heterogeneous distribution of endoplasmic reticulum Ca2+-handling proteins.The Journal of cell biology · 2003Review
- Spatial characterisation of ryanodine-induced calcium release in mouse pancreatic acinar cells.The Biochemical journal · 2003Article
- Regulation of Ca(2+) signaling in rat bile duct epithelia by inositol 1,4,5-trisphosphate receptor isoforms.Hepatology (Baltimore, Md.) · 2002Article
- Localized Ca2+ uncaging reveals polarized distribution of Ca2+-sensitive Ca2+ release sites: mechanism of unidirectional Ca2+ waves.The Journal of cell biology · 2002Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The ryanodine receptor (RyR) is the principal Ca2+-release channel in excitable cells, whereas the inositol 1,4,5-trisphosphate (InsP3) receptor (InsP3R) is primarily responsible for Ca2+ release in non-excitable cells, including epithelia. RyR also is expressed in a number of non-excitable cell types, but is thought to serve as an auxiliary or alternative Ca2+-release pathway in those cells. Here we use reverse transcription PCR to show that a polarized epithelium, the pancreatic acinar cell, expresses the type 2, but not the type 1 or 3, isoform of RyR. We furthermore use immunochemistry to demonstrate that the type 2 RyR is distributed throughout the basolateral and, to a lesser extent, the apical region of the acinar cell, but is excluded from the trigger zone, where cytosolic Ca2+ signals originate in this cell type. Since propagation of Ca2+ waves in acinar cells is sensitive to ryanodine, caffeine and Ca2+, these findings suggest that Ca2+ waves in this cell type result from the co-ordinated release of Ca2+, first from InsP3Rs in the trigger zone, then from RyRs elsewhere in the cell. RyR may play a fundamental role in Ca2+ signalling in polarized epithelia, including for Ca2+ signals initiated by InsP3.
Indexed as
Identifiers
9882629PMC1219966W2043183187What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.