ArticleJournal of virology1999
Polyomavirus large T antigen binds the transcriptional coactivator protein p300.
Article in Journal of virology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Adenovirus E1A binding to DCAF10 targets proteasomal degradation of RUVBL1/2 AAA+ ATPases required for quaternary assembly of multiprotein machines, innate immunity, and responses to metabolic stress.Journal of virology · 2023Article
- Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53.Journal of virology · 2006Article
- Activation of CREB/ATF sites by polyomavirus large T antigen.Journal of virology · 2005Article
- Transactivation of E2F-regulated genes by polyomavirus large T antigen: evidence for a two-step mechanism.Molecular and cellular biology · 2004Article
- Polyomavirus tumorantigens have a profound effect on gene expression in mouse fibroblasts.Oncogene · 2004Article
- Stimulation of DNA replication from the polyomavirus origin by PCAF and GCN5 acetyltransferases: acetylation of large T antigen.Molecular and cellular biology · 2002Article
- Induction and bypass of p53 during productive infection by polyomavirus.Journal of virology · 2002Article
- Transactivation of murine cyclin A by polyomavirus large and small T antigens.Journal of virology · 2001Article
- Effect on polyomavirus T-antigen function of mutations in a conserved leucine-rich segment of the DnaJ domain.Journal of virology · 2001Article
- Article
- A novel transcriptional repression domain mediates p21(WAF1/CIP1) induction of p300 transactivation.Molecular and cellular biology · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using coimmunoprecipitation and glutathione S-transferase pulldown experiments, we found that polyomavirus large T antigen binds to p300 in vivo and in vitro. The N-terminal region of the viral protein, including the pRB binding motif, was dispensable for this interaction, which involved several regions within the C-terminal half of the large T antigen. Interestingly, anti-T antibody coimmunoprecipitated a subspecies of p300 which has high histone acetyltransferase activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.