ArticleDigestive diseases and sciences1998
Changes in plasma and colonic mucosa fatty acid profiles in rats with ulcerative colitis induced by trinitrobenzene sulfonic acid.
Article in Digestive diseases and sciences, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
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- Gut melatonin response to microbial infection in carp Catla catla.Fish physiology and biochemistry · 2016Article
- Paediatric inflammatory bowel disease: a mechanistic approach to investigate exclusive enteral nutrition treatment.Scientifica · 2014Review
- New insights into the role of fatty acids in the pathogenesis and resolution of inflammatory bowel disease.Inflammatory bowel diseases · 2011Review
- Article
- Ethanol and arachidonic acid synergize to activate Kupffer cells and modulate the fibrogenic response via tumor necrosis factor alpha, reduced glutathione, and transforming growth factor beta-dependent mechanisms.Hepatology (Baltimore, Md.) · 2008Article
- Detection of inflammatory bowel disease by proton magnetic resonance spectroscopy (1H MRS) using an animal model.Journal of inflammation (London, England) · 2007Article
- Contribution of polyunsaturated fatty acids to intestinal repair in protein-energy malnutrition.Digestive diseases and sciences · 2007Article
- Lipoprotein docosapentaenoic acid is associated with serum matrix metalloproteinase-9 concentration.Lipids in health and disease · 2005Article
- Experimental ulcerative colitis impairs antioxidant defense system in rat intestine.Digestive diseases and sciences · 2000Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyunsaturated fatty acids have a key role in the pathogenesis of inflammatory bowel disease since some of the arachidonic acid-derived eicosanoids have been found to be increased in inflamed intestinal mucosa in the acute phase of human disease. The aim of this study was to prospectively assess plasma and colon mucosa fatty acid patterns in rats with experimental ulcerative colitis. Twenty rats were treated with trinitrobenzene sulfonic acid and 20 with NaCl; two groups were killed after one week and two after two weeks to evaluate colon damage. Plasma was obtained by aortic puncture and colonic mucosa was scraped off and the fatty acid pattern was determined by gas-liquid chromatography. Total, saturated, and monounsaturated plasma fatty acids were significantly higher in both periods of ulcerative colitis as compared to controls. Plasma n-6 fatty acids were increased after treatment, but no significant changes were observed concerning to n-3 fatty acids. With regard to colon mucosa, saturated and monounsaturated fatty acids did not change because of the disease; however, n-6 fatty acids decreased in the first week and increased in the second week and n-3 fatty acids were increased. Changes on the fatty acid distribution in plasma did not parallel to those of colonic mucosa except for 22:6(n-3). We have also found that experimental ulcerative colitis induced by trinitrobenzene sulfonic acid reproduces many of the features related to changes in plasma and colon mucosa fatty acids observed in the human disease.
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