ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Abnormal targeting of developing hippocampal mossy fibers after epileptiform activities via L-type Ca2+ channel activation in vitro.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 53 citations in OpenAlex.
- Adenosine AScientific reports · 2022Article
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- Pathological Targets for Treating Temporal Lobe Epilepsy: Discoveries From Microscale to Macroscale.Frontiers in neurology · 2021Review
- Astrocyte Role in Temporal Lobe Epilepsy and Development of Mossy Fiber Sprouting.Frontiers in cellular neuroscience · 2021Review
- The Paroxysmal Depolarization Shift: Reconsidering Its Role in Epilepsy, Epileptogenesis and Beyond.International journal of molecular sciences · 2019Review
- KIF2A regulates the development of dentate granule cells and postnatal hippocampal wiring.eLife · 2018Article
- Is Mossy Fiber Sprouting a Potential Therapeutic Target for Epilepsy?Frontiers in neurology · 2018Review
- Article
- Ex vivo cultured neuronal networks emit in vivo-like spontaneous activity.The journal of physiological sciences : JPS · 2014Article
- Building and manipulating neural pathways with microfluidics.Lab on a chip · 2010Article
- Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Article
- Integrative spike dynamics of rat CA1 neurons: a multineuronal imaging study.The Journal of physiology · 2006Article
- Repair of the injured adult hippocampus through graft-mediated modulation of the plasticity of the dentate gyrus in a rat model of temporal lobe epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Chronometric readout from a memory trace: gamma-frequency field stimulation recruits timed recurrent activity in the rat CA3 network.The Journal of physiology · 2004Article
- Brain-derived neurotrophic factor induces hyperexcitable reentrant circuits in the dentate gyrus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Mossy fiber pathfinding in multilayer organotypic cultures of rat hippocampal slices.Cellular and molecular neurobiology · 2003Article
- Group II metabotropic glutamate receptor activation is required for normal hippocampal mossy fibre development in the rat.The Journal of physiology · 2002Article
- Cyclic nucleotide-mediated regulation of hippocampal mossy fiber development: a target-specific guidance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hippocampal mossy fibers, which originate from the dentate granule cells, develop mainly in the early postnatal period and are involved in numerous pathological processes. In this study, hippocampal slices prepared from premature rats were cultivated in the presence of convulsants to evaluate the influences of epileptiform activities on mossy fiber ontogeny. Electrophysiological and histochemical analyses revealed that prolonged hyperexcitability inhibited proper growth of the mossy fibers and caused ectopic innervation to the stratum oriens and the dentate molecular layer. These phenomena were prevented by pharmacological blockade of L-type Ca2+ channels, which did not affect convulsant-evoked ictal bursts. After single-pulse stimulation of the stratum granulosum in the slices cultured under paroxysmal conditions, the dentate gyrus displayed excessive excitation, but synaptic transmission to the CA3 region was hypoactive. However, brief repetitive stimulation elicited delayed epileptiform discharges in the CA3 region that were inhibited by an NMDA receptor antagonist. Chronic treatment with an L-type Ca2+ channel blocker ameliorated such aberrant neurotransmissions. These results suggest that ictal neuron activities at the developmental stage of the mossy fibers bring about the errant maturation associated with hippocampal dysfunction, which may form a cellular basis for the sequelae of childhood epilepsy, including chronic epilepsy or cognitive deficits. Thus I propose that L-type Ca2+ channel blockers can ameliorate the aversive prognosis of childhood epilepsy.
Indexed as
Identifiers
9880600PMC6782205W2116082916What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.