ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
A persistent activity-dependent facilitation in chromaffin cells is caused by Ca2+ activation of protein kinase C.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The trial behind it
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Who cites it
33 citing papers in PubMed, 63 citations in OpenAlex.
- Concentration of stimulant regulates initial exocytotic molecular plasticity at single cells.Chemical science · 2022Article
- Mass Spectrometric Imaging of Plasma Membrane Lipid Alteration Correlated with Amperometrically Measured Activity-Dependent Plasticity in Exocytosis.International journal of molecular sciences · 2020Article
- Acute lung injury in neonatal rats causes postsynaptic depression in nucleus tractus solitarii second-order neurons.Respiratory physiology & neurobiology · 2019Article
- Plasticity in exocytosis revealed through the effects of repetitive stimuli affect the content of nanometer vesicles and the fraction of transmitter released.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Unraveling the mechanisms of calcium-dependent secretion.The Journal of general physiology · 2019Review
- Regulation of insulin exocytosis by calcium-dependent protein kinase C in beta cells.Cell calcium · 2017Review
- Pituitary adenylate cyclase-activating peptide (PACAP) recruits low voltage-activated T-type calcium influx under acute sympathetic stimulation in mouse adrenal chromaffin cells.The Journal of biological chemistry · 2011Article
- Ethanol modulation of synaptic plasticity.Neuropharmacology · 2011Review
- Phosphorylation of SNAP-25 at Ser187 mediates enhancement of exocytosis by a phorbol ester in INS-1 cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Matching native electrical stimulation by graded chemical stimulation in isolated mouse adrenal chromaffin cells.Journal of neuroscience methods · 2007Article
- Increased secretory capacity of mouse adrenal chromaffin cells by chronic intermittent hypoxia: involvement of protein kinase C.The Journal of physiology · 2007Article
- Protein kinase C regulates local synthesis and secretion of a neuropeptide required for activity-dependent long-term synaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Ca2+-secretion coupling is impaired in diabetic Goto Kakizaki rats.The Journal of general physiology · 2007Article
- Phosphomimetic mutation of Ser-187 of SNAP-25 increases both syntaxin binding and highly Ca2+-sensitive exocytosis.The Journal of general physiology · 2007Article
- Munc13-1 C1 domain activation lowers the energy barrier for synaptic vesicle fusion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Potentiation of exocytosis by phospholipase C-coupled G-protein-coupled receptors requires the priming protein Munc13-1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Physiological stimulation regulates the exocytic mode through calcium activation of protein kinase C in mouse chromaffin cells.The Biochemical journal · 2006Article
- Involvement of protein kinase C-epsilon in activity-dependent potentiation of large dense-core vesicle exocytosis in chromaffin cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Syntillas release Ca2+ at a site different from the microdomain where exocytosis occurs in mouse chromaffin cells.Biophysical journal · 2006Article
- Modulation of neurotransmitter release by the second messenger-activated protein kinases: implications for presynaptic plasticity.Pharmacology & therapeutics · 2005Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activity-dependent facilitation was studied in bovine adrenal chromaffin cells. Stimulation with a train of depolarizations caused subsequent triggered exocytotic activity to be significantly enhanced. After the facilitating stimulus train, the readily releasable vesicle pool (RRP) size was estimated from capacitance jumps in response to paired depolarizations and found to be elevated for a period of at least 10 min. The time dependency of onset and degree of facilitation could be well fitted assuming protein kinase C (PKC)-dependent and independent Ca2+-mediated processes. Both processes increase the recruitment of vesicles from the reserve pool to the RRP, resulting in an greater number of releasable vesicles. The data suggest that cell activity can act as a trigger to increase cytosolic Ca2+ to a level sufficient to cause an increase in the number of readily releasable secretory vesicles, with the more persistent component of the evoked facilitation being mediated through activity-dependent activation of PKC.
Indexed as
Identifiers
9880579PMC6782191W1571965370What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.