ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Identification of an acute ethanol response quantitative trait locus on mouse chromosome 2.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- BXD Recombinant Inbred Mice as a Model to Study Neurotoxicity.Biomolecules · 2021Review
- Genomic mapping in outbred mice reveals overlap in genetic susceptibility for HZE ion- and γ-ray-induced tumors.Science advances · 2020Article
- Post-genomic behavioral genetics: From revolution to routine.Genes, brain, and behavior · 2018Review
- Integrating Genetic and Gene Co-expression Analysis Identifies Gene Networks Involved in Alcohol and Stress Responses.Frontiers in molecular neuroscience · 2018Article
- Identification of quantitative trait loci and candidate genes for an anxiolytic-like response to ethanol in BXD recombinant inbred strains.Genes, brain, and behavior · 2016Article
- Behavioral and Genetic Evidence for GIRK Channels in the CNS: Role in Physiology, Pathophysiology, and Drug Addiction.International review of neurobiology · 2015Review
- Article
- Genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice.PloS one · 2014Article
- High-precision genetic mapping of behavioral traits in the diversity outbred mouse population.Genes, brain, and behavior · 2013Article
- The α6 nicotinic acetylcholine receptor subunit influences ethanol-induced sedation.Alcohol (Fayetteville, N.Y.) · 2012Article
- Discovering genes involved in alcohol dependence and other alcohol responses: role of animal models.Alcohol research : current reviews · 2012Article
- Mapping quantitative traits and strategies to find quantitative trait genes.Methods (San Diego, Calif.) · 2011Review
- A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice.PloS one · 2010Article
- A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models.Addiction biology · 2010Review
- High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains.Genes, brain, and behavior · 2010Article
- Evidence of long-term expression of behavioral sensitization to both cocaine and ethanol in dopamine transporter knockout mice.Psychopharmacology · 2010Article
- Mapping a barbiturate withdrawal locus to a 0.44 Mb interval and analysis of a novel null mutant identify a role for Kcnj9 (GIRK3) in withdrawal from pentobarbital, zolpidem, and ethanol.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Bone, muscle, and physical activity: structural equation modeling of relationships and genetic influence with age.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2009Article
- Article
- QTL analyses of temporal and intensity components of home-cage activity in KJR and C57BL/6J strains.BMC genetics · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
A two-stage strategy was used to identify and confirm quantitative trait loci (QTLs) associated with the changes in locomotor activity induced by a 1.5 gm/kg ethanol challenge. For stage 1, putative QTLs were identified by analysis of the strain means for 25 strains of the BXD recombinant inbred (RI) series (males only). QTLs were identified on chromosomes 1, 2, 4, and 6. The activity response to chlordiazepoxide generated similar QTLs on chromosomes 2 and 6. None of the QTLs were similar to those generated from analysis of the saline response data. For stage 2, 900 male C57BL/6J (B6) x DBA/2J (D2) F2 intercross animals were phenotyped for ethanol response, and the phenotypic extremes (those animals > and <1 SD from the mean) were identified. These extremes differed by >10,000 cm/15 min in their response to ethanol. The extreme progeny were used for a genome-wide scan both to confirm the putative RI-generated QTLs and to detect new QTLs. The F2 analysis generated no new QTLs with logarithm of the likelihood for linkage (LOD) scores >3. For RI-generated QTLs, only the QTL on chromosome 2 was confirmed (LOD = 5.3). The position of the peak LOD was estimated to be 47 cM with a 20 cM 1 LOD support interval; this QTL accounted for 6% of the phenotypic variance. The 1 LOD support interval overlaps with QTLs previously identified for alcohol preference and acute ethanol withdrawal (;; ).
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