ArticlePlant physiology1999
Arachidonic acid alters tomato HMG expression and fruit growth and induces 3-hydroxy-3-methylglutaryl coenzyme A reductase-independent lycopene accumulation
Article in Plant physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 56 citations in OpenAlex.
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- Comparative Metabolites and Citrate-Degrading Enzymes Activities in Citrus Fruits Reveal the Role of Balance between ACL and Cyt-ACO in Metabolite Conversions.Plants (Basel, Switzerland) · 2020Article
- Improved fruit α-tocopherol, carotenoid, squalene and phytosterol contents through manipulation of Brassica juncea 3-HYDROXY-3-METHYLGLUTARYL-COA SYNTHASE1 in transgenic tomato.Plant biotechnology journal · 2018Article
- The impact of sodium nitroprusside and ozone in kiwifruit ripening physiology: a combined gene and protein expression profiling approach.Annals of botany · 2015Article
- Both the mevalonate and the non-mevalonate pathways are involved in ginsenoside biosynthesis.Plant cell reports · 2014Article
- β-glucans and eicosapolyenoic acids as MAMPs in plant-oomycete interactions: past and present.Frontiers in plant science · 2014Review
- A large-scale identification of direct targets of the tomato MADS box transcription factor RIPENING INHIBITOR reveals the regulation of fruit ripening.The Plant cell · 2013Article
- Transcriptome and metabolite profiling show that APETALA2a is a major regulator of tomato fruit ripening.The Plant cell · 2011Article
- Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways.Plant cell reports · 2007Article
- Identification of primary target genes of phytochrome signaling. Early transcriptional control during shade avoidance responses in Arabidopsis.Plant physiology · 2006Article
- Changes in transcriptional profiles are associated with early fruit tissue specialization in tomato.Plant physiology · 2005Article
- Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development.The Plant cell · 2004Article
- Article
- Crosstalk between cytosolic and plastidial pathways of isoprenoid biosynthesis in Arabidopsis thaliana.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Control of photoperiod-regulated tuberization in potato by the Arabidopsis flowering-time gene CONSTANS.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Regulation of squalene synthase, a key enzyme of sterol biosynthesis, in tobacco.Plant physiology · 2002Article
- LEFPS1, a tomato farnesyl pyrophosphate gene highly expressed during early fruit development.Plant physiology · 2000Article
- The prenylation status of a novel plant calmodulin directs plasma membrane or nuclear localization of the protein.The EMBO journal · 1999Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulation of isoprenoid end-product synthesis required for normal growth and development in plants is not well understood. To investigate the extent to which specific genes for the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) are involved in end-product regulation, we manipulated expression of the HMG1 and HMG2 genes in tomato (Lycopersicon esculentum) fruit using arachidonic acid (AA). In developing young fruit AA blocked fruit growth, inhibited HMG1, and activated HMG2 expression. These results are consistent with other reports indicating that HMG1 expression is closely correlated with growth processes requiring phytosterol production. In mature-green fruit AA strongly induced the expression of HMG2, PSY1 (the gene for phytoene synthase), and lycopene accumulation before the normal onset of carotenoid synthesis and ripening. The induction of lycopene synthesis was not blocked by inhibition of HMGR activity using mevinolin, suggesting that cytoplasmic HMGR is not required for carotenoid synthesis. Our results are consistent with the function of an alternative plastid isoprenoid pathway (the Rohmer pathway) that appears to direct the production of carotenoids during tomato fruit ripening.
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