ArticleBMJ (Clinical research ed.)1999
A simple computer program for guiding management of cardiovascular risk factors and prescribing.
Article in BMJ (Clinical research ed.), 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 6 syntheses or guidelines pooled it, 119 citations in OpenAlex.
- Clinical assessment of patients with chest pain; a systematic review of predictive tools.BMC cardiovascular disorders · 2016Pooled it
- Cardiovascular risk assessment scores for people with diabetes: a systematic review.Diabetologia · 2009Pooled it
- Relative risk of diabetes, dyslipidaemia, hypertension and the metabolic syndrome in people with severe mental illnesses: systematic review and metaanalysis.BMC psychiatry · 2008Pooled it
- More in hope than expectation: a systematic review of women's expectations and experience of pain relief in labour.BMC medicine · 2008Pooled it
- Prediction of mortality from coronary heart disease among diverse populations: is there a common predictive function?Heart (British Cardiac Society) · 2002Pooled it
- Use of lipid lowering drugs for primary prevention of coronary heart disease: meta-analysis of randomised trials.BMJ (Clinical research ed.) · 2000Pooled it
- One-year follow-up of a therapeutic lifestyle intervention targeting cardiovascular disease risk.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2007Trial
- Evaluation of computer based clinical decision support system and risk chart for management of hypertension in primary care: randomised controlled trial.BMJ (Clinical research ed.) · 2000Trial
- Making predictions under interventions: a case study from the PREDICT-CVD cohort in New Zealand primary care.Frontiers in epidemiology · 2024Article
- Observational
- Applying the Framingham risk score for prediction of metabolic syndrome: The Kerman Coronary Artery Disease Risk Study, Iran.ARYA atherosclerosis · 2015Article
- The difference in blood pressure readings between arms and survival: primary care cohort study.BMJ (Clinical research ed.) · 2012Article
- A new Web-based medical tool for assessment and prevention of comprehensive cardiovascular risk.Therapeutics and clinical risk management · 2011Article
- Absolute risk representation in cardiovascular disease prevention: comprehension and preferences of health care consumers and general practitioners involved in a focus group study.BMC public health · 2010Article
- Cardiovascular outcomes in the outpatient kidney transplant clinic: the Framingham risk score revisited.Clinical journal of the American Society of Nephrology : CJASN · 2008Article
- Incidence of coronary artery disease in siblings of patients with premature coronary artery disease: 10 years of follow-up.The American journal of cardiology · 2007Article
- The interarm blood pressure difference as predictor of cardiovascular events in patients with hypertension in primary care: cohort study.Journal of human hypertension · 2007Article
- Article
- Prediction of depression in European general practice attendees: the PREDICT study.BMC public health · 2006Article
- Aspirin for the prevention of cardiovascular disease: calculating benefit and harm in the individual patient.British journal of clinical pharmacology · 2003Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo describe, and to test against trial data, a simple and flexible computer program for calculating cardiovascular risk in individual patients as an aid to managing risk factors and prescribing drugs to lower cholesterol concentration and blood pressure.
designDescriptive comparison of actual cardiovascular risk in randomised controlled trials of cholesterol reduction with risk predicted by a computer program based on the Framingham risk equation. Comparison of the program's performance with that of tables and guidelines by means of hypothetical case examples.
main outcome measuresAverage risk of coronary heart disease and myocardial infarction.
resultsThe computer program accurately predicted baseline absolute risk in a UK population as well as the relative and absolute reduction in risk from cholesterol lowering for primary prevention of coronary heart disease. The program also allowed a more refined estimate of absolute risk of coronary heart disease than some existing tables and enabled the impact of prescribing decisions to be quantified and costed.
conclusionsThis simple computer program to estimate individuals' cardiovascular disease risk and display the benefits of intervention should help clinicians and patients decide on the most effective packages of risk reduction and identify those most likely to benefit from modulation of risk factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.