ArticleThe Plant cell1999
A mutation in the pale aleurone color1 gene identifies a novel regulator of the maize anthocyanin pathway.
Article in The Plant cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 86 citations in OpenAlex.
- Comparative transcriptomics of anthocyanin accumulation in the pericarp of pigmented purple corn.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Unraveling the genetic and molecular mechanisms of anthocyanin biosynthesis and accumulation in maize kernels.Frontiers in plant science · 2026Review
- Loss of Pleiotropic Regulatory Functions inPlant direct · 2025Article
- Regulation of Flavonoid Biosynthesis by the MYB-bHLH-WDR (MBW) Complex in Plants and Its Specific Features in Cereals.International journal of molecular sciences · 2025Review
- Genome-wide association study of kernel colour traits and mining of elite alleles from the major loci in maize.BMC plant biology · 2024Article
- Comparative transcriptomic and metabolomic analysis reveals mechanisms of selenium-regulated anthocyanin synthesis in waxy maize (Frontiers in plant science · 2024Article
- R3-MYB repressor Mybr97 is a candidate gene associated with the Anthocyanin3 locus and enhanced anthocyanin accumulation in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Maize Flavonoid Biosynthesis, Regulation, and Human Health Relevance: A Review.Molecules (Basel, Switzerland) · 2022Review
- Uncovering Hierarchical Regulation among MYB-bHLH-WD40 Proteins and Manipulating Anthocyanin Pigmentation in Rice.International journal of molecular sciences · 2022Article
- Development and Application of Fruit Color-Related Expressed Sequence Tag-Simple Sequence Repeat Markers inFrontiers in plant science · 2022Article
- Prospects for economical natural colorants: insights from maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Review
- Transcriptome and Proteome Profiling of Different Colored Rice Reveals Physiological Dynamics Involved in the Flavonoid Pathway.International journal of molecular sciences · 2019Article
- A Large-Scale Genome-Wide Association Analyses of Ethiopian Sorghum Landrace Collection Reveal Loci Associated With Important Traits.Frontiers in plant science · 2019Article
- TRANSPARENT TESTA GLABRA 1-Dependent Regulation of Flavonoid Biosynthesis.Plants (Basel, Switzerland) · 2017Review
- Regulation of plant secondary metabolism and associated specialized cell development by MYBs and bHLHs.Phytochemistry · 2016Review
- Characterization of factors underlying the metabolic shifts in developing kernels of colored maize.Scientific reports · 2016Article
- Transciptome analysis reveals flavonoid biosynthesis regulation and simple sequence repeats in yam (Dioscorea alata L.) tubers.BMC genomics · 2015Article
- Ternary WD40 Repeat-Containing Protein Complexes: Evolution, Composition and Roles in Plant Immunity.Frontiers in plant science · 2015Review
- Review
- Expression level of a flavonoid 3'-hydroxylase gene determines pathogen-induced color variation in sorghum.BMC research notes · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
By screening for new seed color mutations, we have identified a new gene, pale aleurone color1 (pac1), which when mutated causes a reduction in anthocyanin pigmentation. The pac1 gene is not allelic to any known anthocyanin biosynthetic or regulatory gene. The pac1-ref allele is recessive, nonlethal, and only reduces pigment in kernels, not in vegetative tissues. Genetic and molecular evidence shows that the pac1-ref allele reduces pigmentation by reducing RNA levels of the biosynthetic genes in the pathway. The mutant does not reduce the RNA levels of either of the two regulatory genes, b and c1. Introduction of an anthocyanin structural gene promoter (a1) driving a reporter gene into maize aleurones shows that pac1-ref kernels have reduced expression resulting from the action of the a1 promoter. Introduction of the reporter gene with constructs that express the regulatory genes b and c1 or the phlobaphene pathway regulator p shows that this reduction in a1-driven expression occurs in both the presence and absence of these regulators. Our results imply that pac1 is required for either b/c1 or p activation of anthocyanin biosynthetic gene expression and that pac1 acts independently of these regulatory genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.