ArticleThe EMBO journal1999
Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor.
Article in The EMBO journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 85 citations in OpenAlex.
- Nuclear envelope proteins in cancer: revisiting the significance of LEM-domain proteins.Frontiers in cell and developmental biology · 2026Review
- The role of inner nuclear membrane protein emerin in myogenesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Review
- The Role of Emerin in Cancer Progression and Metastasis.International journal of molecular sciences · 2021Review
- Downregulation of the ubiquitin ligase KBTBD8 prevented epithelial ovarian cancer progression.Molecular medicine (Cambridge, Mass.) · 2020Article
- EDMD-Causing Emerin Mutant Myogenic Progenitors Exhibit Impaired Differentiation Using Similar Mechanisms.Cells · 2020Article
- The ubiquitin ligase KBTBD8 regulates PKM1 levels via Erk1/2 and Aurora A to ensure oocyte quality.Aging · 2019Article
- Double abdomen in a short-germ insect: Zygotic control of axis formation revealed in the beetleProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Diseases of the Nucleoskeleton.Comprehensive Physiology · 2016Review
- Key Role of Amino Acid Repeat Expansions in the Functional Diversification of Duplicated Transcription Factors.Molecular biology and evolution · 2015Article
- The Nuclear Matrix Protein, NRP/B, Acts as a Transcriptional Repressor of E2F-mediated Transcriptional Activity.Journal of cancer prevention · 2014Article
- Emerin in health and disease.Seminars in cell & developmental biology · 2014Review
- A spindle-independent cleavage pathway controls germ cell formation in Drosophila.Nature cell biology · 2013Article
- GAGE cancer-germline antigens are recruited to the nuclear envelope by germ cell-less (GCL).PloS one · 2012Article
- The nuclear envelope at a glance.Journal of cell science · 2010Article
- Role of A-type lamins in signaling, transcription, and chromatin organization.The Journal of cell biology · 2009Review
- Article
- Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment.PLoS genetics · 2009Article
- Sprouty2-mediated inhibition of fibroblast growth factor signaling is modulated by the protein kinase DYRK1A.Molecular and cellular biology · 2008Article
- Laminopathies: multiple disorders arising from defects in nuclear architecture.Journal of biosciences · 2006Review
- Multiple roles for emerin: implications for Emery-Dreifuss muscular dystrophy.The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcription factor E2F plays an important role in orchestrating early cell cycle progression through its ability to co-ordinate and integrate the cell cycle with the transcription apparatus. Physiological E2F arises when members of two distinct families of proteins interact as E2F-DP heterodimers, in which the E2F component mediates transcriptional activation and the physical interaction with pocket proteins, such as the tumour suppressor protein pRb. In contrast, a discrete role for the DP subunit has not been defined. We report the identification and characterization of DIP, a novel mammalian protein that can interact with the DP component of E2F. DIP was found to contain a BTB/POZ domain and shows significant identity with the Drosophila melanogaster germ cell-less gene product. In mammalian cells, DIP is distributed in a speckled pattern at the nuclear envelope region, and can direct certain DP subunits and the associated heterodimeric E2F partner into a similar pattern. DIP-dependent growth arrest is modulated by the expression of DP proteins, and mutant derivatives of DIP that are compromised in cell cycle arrest exhibit reduced binding to the DP subunit. Our study defines a new pathway of growth control that is integrated with the E2F pathway through the DP subunit of the heterodimer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.