ArticleBiophysical journal1999
Weak dependence of mobility of membrane protein aggregates on aggregate size supports a viscous model of retardation of diffusion.
Article in Biophysical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 81 citations in OpenAlex.
- Advancements in Engineering Planar Model Cell Membranes: Current Techniques, Applications, and Future Perspectives.Nanomaterials (Basel, Switzerland) · 2024Review
- Optimization of BRET saturation assays for robust and sensitive cytosolic protein-protein interaction studies.Scientific reports · 2022Article
- Diffusion of Lipid Nanovesicles Bound to a Lipid Membrane Is Associated with the Partial-Slip Boundary Condition.Nano letters · 2021Article
- Cell patterning by secretion-induced plasma membrane flows.Science advances · 2021Article
- Article
- An efficient approach to study membrane nano-inclusions: from the complex biological world to a simple representation.RSC advances · 2021Article
- Physical properties of phospholipids and integral proteins and their biofunctional roles in pulmonary surfactant from molecular dynamics simulation.RSC advances · 2020Article
- Self-Assembly of Polymer-Encased Lipid Nanodiscs and Membrane Protein Reconstitution.The journal of physical chemistry. B · 2019Article
- Impaired Glycine Receptor Trafficking in Neurological Diseases.Frontiers in molecular neuroscience · 2018Review
- Protein Crowding within the Postsynaptic Density Can Impede the Escape of Membrane Proteins.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The impact of physiological crowding on the diffusivity of membrane bound proteins.Soft matter · 2016Article
- There Is No Simple Model of the Plasma Membrane Organization.Frontiers in cell and developmental biology · 2016Review
- Wanted: scalable tracers for diffusion measurements.The journal of physical chemistry. B · 2014Review
- Reconstitution of membrane proteins into model membranes: seeking better ways to retain protein activities.International journal of molecular sciences · 2013Review
- Intracellular trafficking of FXYD1 (phospholemman) and FXYD7 proteins in Xenopus oocytes and mammalian cells.The Journal of biological chemistry · 2012Article
- Article
- Dynamics of a polymer chain confined in a membrane.The European physical journal. E, Soft matter · 2011Article
- Neurexin/neuroligin interaction kinetics characterized by counting single cell-surface attached quantum dots.Biophysical journal · 2009Article
- A molecular clutch between the actin flow and N-cadherin adhesions drives growth cone migration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Lateral mobility of proteins in liquid membranes revisited.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteins in plasma membranes diffuse more slowly than proteins inserted into artificial lipid bilayers. On a long-range scale (>250 nm), submembrane barriers, or skeleton fences that hinder long-range diffusion and create confinement zones, have been described. Even within such confinement zones, however, diffusion of proteins is much slower than predicted by the viscosity of the lipid. The cause of this slowing of diffusion on the micro scale has not been determined and is the focus of this paper. One way to approach this question is to determine the dependence of particle motion on particle size. Some current models predict that the diffusion coefficient of a membrane protein aggregate will depend strongly on its size, while others do not. We have measured the diffusion coefficients of membrane glycoprotein aggregates linked together by concanavalin A molecules bound to beads of various sizes, and also the diffusion coefficients of individual concanavalin A binding proteins. The measurements demonstrate at most a weak dependence of diffusion coefficient on aggregate size. This finding supports retardation by viscous effects, and is not consistent with models involving direct interaction of diffusing proteins with cytoskeletal elements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.