ArticleBiophysical journal1999
Physical origin of selectivity in ionic channels of biological membranes.
Article in Biophysical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 80 citations in OpenAlex.
- Tuneable ion selectivity in vermiculite membranes intercalated with unexchangeable ions.Nature communications · 2025Article
- Li-ion transport in two-dimensional nanofluidic membranes.Nano convergence · 2024Review
- SARS-CoV spike proteins can compete for electrolytes in physiological fluids according to structure-based quantum-chemical calculations.Computational & theoretical chemistry · 2021Article
- Design principles of ion selective nanostructured membranes for the extraction of lithium ions.Nature communications · 2019Review
- The permeation mechanism of organic cations through a CNG mimic channel.PLoS computational biology · 2018Article
- Structural Heterogeneity of CNGA1 Channels Revealed by Electrophysiology and Single-Molecule Force Spectroscopy.ACS omega · 2016Article
- A structural, functional, and computational analysis suggests pore flexibility as the base for the poor selectivity of CNG channels.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Gating of cyclic nucleotide-gated channels is voltage dependent.Nature communications · 2012Article
- Gating in CNGA1 channels.Pflugers Archiv : European journal of physiology · 2010Review
- Conformational changes in the selectivity filter of the open-state KcsA channel: an energy minimization study.Biophysical journal · 2008Article
- Hydration of potassiated amino acids in the gas phase.Journal of the American Society for Mass Spectrometry · 2007Article
- Effects of exogenous electromagnetic fields on a simplified ion channel model.Journal of biological physics · 2007Article
- A homology model of the pore region of HCN channels.Biophysical journal · 2005Article
- Mechanism of anionic conduction across ClC.Biophysical journal · 2004Article
- Pore topology of the hyperpolarization-activated cyclic nucleotide-gated channel from sea urchin sperm.Biophysical journal · 2002Article
- The chloroplast protein import channel Toc75: pore properties and interaction with transit peptides.Biophysical journal · 2002Article
- The interaction of Na(+) and K(+) in the pore of cyclic nucleotide-gated channels.Biophysical journal · 2000Article
- Molecular determinants of anion selectivity in the cystic fibrosis transmembrane conductance regulator chloride channel pore.Biophysical journal · 2000Article
- General anesthetic binding to gramicidin A: the structural requirements.Biophysical journal · 2000Article
- Forces determining ion permeation.The Journal of general physiology · 1999Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper shows that the selectivity properties of monovalent cation channels found in biological membranes can originate simply from geometrical properties of the inner core of the channel without any critical contribution from electrostatic interactions between the permeating ions and charged or polar groups. By using well-known techniques of statistical mechanics, such as the Langevin equations and Kramer theory of reaction rates, a theoretical equation is provided relating the permeability ratio PB/PA between ions A and B to simple physical properties, such as channel geometry, thermodynamics of ion hydration, and electrostatic interactions between the ion and charged (or polar) groups. Diffusive corrections and recrossing rates are also considered and evaluated. It is shown that the selectivity found in usual K+, gramicidin, Na+, cyclic nucleotide gated, and end plate channels can be explained also in the absence of any charged or polar group. If these groups are present, they significantly change the permeability ratio only if the ion at the selectivity filter is in van der Waals contact with them, otherwise these groups simply affect the channel conductance, lowering the free energy barrier of the same amount for the two ions, thus explaining why single channel conductance, as it is experimentally observed, can be very different in channels sharing the same selectivity sequence. The proposed theory also provides an estimate of channel minimum radius for K+, gramicidin, Na+, and cyclic nucleotide gated channels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.