ArticleBiophysical journal1999
Hydrodynamics of micropipette aspiration.
Article in Biophysical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Micropipette aspiration reveals differential RNA-dependent viscoelasticity of nucleolar subcompartments.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Low-cost robotic manipulation of live microtissues for cancer drug testing.Science advances · 2025Article
- Live-cell quantification reveals viscoelastic regulation of synapsin condensates by α-synuclein.Science advances · 2025Article
- A calibration-free model of micropipette aspiration for measuring properties of protein condensates.Biophysical journal · 2024Article
- Integrative experimental/computational approach establishes active cellular protrusion as the primary driving force of phagocytic spreading by immune cells.PLoS computational biology · 2022Article
- The biophysics of cancer: emerging insights from micro- and nanoscale tools.Advanced nanobiomed research · 2022Article
- Surface tension and viscosity of protein condensates quantified by micropipette aspiration.Biophysical reports · 2021Article
- Experimental study of the difference in deformation between normal and pathological, renal and bladder, cells induced by acoustic radiation force.European biophysics journal : EBJ · 2020Article
- Mechanics and stability of vesicles and droplets in confined spaces.Physical review. E · 2016Article
- Universal behavior of hydrogels confined to narrow capillaries.Scientific reports · 2015Article
- Entry effects of droplet in a micro confinement: Implications for deformation-based circulating tumor cell microfiltration.Biomicrofluidics · 2015Article
- Cytopede: a three-dimensional tool for modeling cell motility on a flat surface.Journal of computational biology : a journal of computational molecular cell biology · 2010Article
- Modeling cell interactions under flow.Journal of mathematical biology · 2009Review
- Recoil and stiffening by adherent leukocytes in response to fluid shear.Biophysical journal · 2008Article
- Article
- Estimating the sensitivity of mechanosensitive ion channels to membrane strain and tension.Biophysical journal · 2004Article
- Computational modeling of cell adhesion and movement using a continuum-kinetics approach.Biophysical journal · 2003Article
- The mechanics of neutrophils: synthetic modeling of three experiments.Biophysical journal · 2003Article
- Neutrophil transit times through pulmonary capillaries: the effects of capillary geometry and fMLP-stimulation.Biophysical journal · 2002Article
- Determination of cellular strains by combined atomic force microscopy and finite element modeling.Biophysical journal · 2002Article
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Authors and funding
2 authors.
Funding
Abstract
The dynamics of human neutrophils during micropipette aspiration are frequently analyzed by approximating these cells as simple slippery droplets of viscous fluid. Here, we present computations that reveal the detailed predictions of the simplest and most idealized case of such a scheme; namely, the case where the fluid of the droplet is homogeneous and Newtonian, and the surface tension of the droplet is constant. We have investigated the behavior of this model as a function of surface tension, droplet radius, viscosity, aspiration pressure, and pipette radius. In addition, we have tabulated a dimensionless factor, M, which can be utilized to calculate the apparent viscosity of the slippery droplet. Computations were carried out using a low Reynolds number hydrodynamics transport code based on the finite-element method. Although idealized and simplistic, we find that the slippery droplet model predicts many observed features of neutrophil aspiration. However, there are certain features that are not observed in neutrophils. In particular, the model predicts dilation of the membrane past the point of being continuous, as well as a reentrant jet at high aspiration pressures.
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