ArticleArchives of disease in childhood1998
Antineutrophil cytoplasmic antibodies in Wegener's granulomatosis.
Article in Archives of disease in childhood, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Childhood-onset granulomatosis with polyangiitis and microscopic polyangiitis: systematic review and meta-analysis.Orphanet journal of rare diseases · 2016Pooled it
- Adolescent PR3-ANCA-positive hypertrophic pachymeningitis: A case report and review of the literature.Medicine · 2018Article
- Lung involvement in childhood onset granulomatosis with polyangiitis.Pediatric rheumatology online journal · 2017Review
- Disease risk factors identified through shared genetic architecture and electronic medical records.Science translational medicine · 2014Article
- Long- term outcome of paediatric patients with ANCA vasculitis.Pediatric rheumatology online journal · 2011Article
- Medium-size-vessel vasculitis.Pediatric nephrology (Berlin, Germany) · 2010Review
- Article
- Wegener's Granulomatosis with Fungal Lung Infection in a Child.Medical journal, Armed Forces India · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of antineutrophil cytoplasmic antibodies (ANCA) was studied in 12 children with Wegener's granulomatosis. The serum samples were taken in the active phase of disease and were screened for ANCA by indirect immunofluorescence with normal neutrophils and enzyme linked immunosorbent assay (ELISA) using crude neutrophil extract, proteinase 3, myeloperoxidase, cathepsin G, lactoferrin, and elastase as antigens. Of these 12 patients, 10 wre positive for ANCA in the active phase of their illness, and they showed a predominantly cytoplasmic ANCA staining pattern on indirect immunofluorescence. There were high titres of ANCA directed against crude neutrophil extract, proteinase 3, myeloperoxidase, and cathepsin G. IgM isotypes occurred as commonly as IgG isotypes. Therefore, screening for ANCA is usually but not invariably positive in children with Wegener's granulomatosis. Specific diagnosis still relies on clinical and pathological features, and the value of ANCA in the diagnosis of paediatric Wegener's granulomatosis requires further study.
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