ArticleProceedings of the National Academy of Sciences of the United States of America1999
Segregation of steroid receptor coactivator-1 from steroid receptors in mammary epithelium.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 68 citations in OpenAlex.
- Plasticity of Signaling by Spinal Estrogen Receptor α, κ-Opioid Receptor, and Metabotropic Glutamate Receptors over the Rat Reproductive Cycle Regulates Spinal Endomorphin 2 Antinociception: Relevance of Endogenous-Biased Agonism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Article
- Overcoming Resistance to Endocrine Therapy in Breast Cancer: New Approaches to a Nagging Problem.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2016Review
- Spinal synthesis of estrogen and concomitant signaling by membrane estrogen receptors regulate spinal κ- and μ-opioid receptor heterodimerization and female-specific spinal morphine antinociception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Nuclear receptor coactivators are coexpressed with steroid receptors and regulated by estradiol in mouse brain.Neuroendocrinology · 2011Article
- Adaptation to estradiol deprivation causes up-regulation of growth factor pathways and hypersensitivity to estradiol in breast cancer cells.Advances in experimental medicine and biology · 2008Review
- Cells in behaviourally relevant brain regions coexpress nuclear receptor coactivators and ovarian steroid receptors.Journal of neuroendocrinology · 2007Article
- Localization of estrogen receptors alpha and beta in the articular surface of the rat femur.Acta histochemica et cytochemica · 2007Article
- Pubertal mammary gland development: insights from mouse models.Journal of mammary gland biology and neoplasia · 2006Review
- Nuclear receptor coactivator function in reproductive physiology and behavior.Biology of reproduction · 2003Review
- Supervillin associates with androgen receptor and modulates its transcriptional activity.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Attenuation of the self-renewal of transit-amplifying osteoblast progenitors in the murine bone marrow by 17 beta-estradiol.The Journal of clinical investigation · 2001Article
- Endogenously expressed estrogen receptor and coactivator AIB1 interact in MCF-7 human breast cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- The role of coactivators and corepressors in the biology and mechanism of action of steroid hormone receptors.Journal of mammary gland biology and neoplasia · 2000Review
- A reappraisal of progesterone action in the mammary gland.Journal of mammary gland biology and neoplasia · 2000Review
- Steroid receptor coactivator-1 (SRC-1) mediates the development of sex-specific brain morphology and behavior.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Estrogen receptor transcription and transactivation: Estrogen receptor alpha and estrogen receptor beta: regulation by selective estrogen receptor modulators and importance in breast cancer.Breast cancer research : BCR · 2000Review
- Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- P/CAF associates with cyclin D1 and potentiates its activation of the estrogen receptor.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Steroid receptor coactivator-1 (SRC-1) family members interact with steroid receptors, including estrogen receptor alpha (ERalpha) and progesterone receptor (PR), to enhance ligand-dependent transcription. However, the expression of ERalpha and SRC-1 was found to be segregated in distinct subsets of cells within the epithelium of the estrogen-responsive rat mammary gland. This finding was in contrast to the finding for the stroma, where significant numbers of cells coexpressed ERalpha and SRC-1. Treatment of animals with estrogen induced PR expression in the ERalpha-expressing mammary epithelial cells in the absence of detectable SRC-1 and did not affect the segregated pattern of SRC-1 and ERalpha expression. PR was neither expressed nor induced by estrogen treatment in stroma, despite the coexpression of ERalpha and SRC-1. These results suggest that SRC-1 is not necessary for ERalpha-mediated induction of PR in mammary epithelial cells and is also not sufficient for PR induction in stromal cells expressing both ERalpha and SRC-1. Furthermore, the expression of SRC-1 in a subpopulation of mammary epithelial cells distinct from those expressing ERalpha or PR raises the possibility that SRC-1 has cell type-specific functions other than simply to act as coactivator for ERalpha or PR in the mammary epithelium.
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