ArticleThe Journal of experimental medicine1999
Molecular recognition of lipid antigens by T cell receptors.
Article in The Journal of experimental medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
66 citing papers in PubMed, 166 citations in OpenAlex.
- Polyphenol-Mediated Engineering of Lipid Nanoparticles With Crystalline Mesophases.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Characterization ofJournal of immunology (Baltimore, Md. : 1950) · 2022Article
- Fat and Protein Combat Triggers Immunological Weapons of Innate and Adaptive Immune Systems to Launch Neuroinflammation in Parkinson's Disease.International journal of molecular sciences · 2022Review
- Differential skewing of donor-unrestricted and γδ T cell repertoires in tuberculosis-infected human lungs.The Journal of clinical investigation · 2020Article
- A TCR β-Chain Motif Biases toward Recognition of Human CD1 Proteins.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Molecular recognition of microbial lipid-based antigens by T cells.Cellular and molecular life sciences : CMLS · 2018Review
- Immune monitoring and TCR sequencing of CD4 T cells in a long term responsive patient with metastasized pancreatic ductal carcinoma treated with individualized, neoepitope-derived multipeptide vaccines: a case report.Journal of translational medicine · 2018Article
- How T cells grasp mycobacterial lipid antigens.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- CD1b-mycolic acid tetramers demonstrate T-cell fine specificity for mycobacterial lipid tails.European journal of immunology · 2017Article
- Donor-unrestricted T cells in the human CD1 system.Immunogenetics · 2016Review
- Article
- Lipid and small-molecule display by CD1 and MR1.Nature reviews. Immunology · 2015Review
- Donor Unrestricted T Cells: A Shared Human T Cell Response.Journal of immunology (Baltimore, Md. : 1950) · 2015Review
- Modeling T cell receptor recognition of CD1-lipid and MR1-metabolite complexes.BMC bioinformatics · 2014Article
- TCR bias and affinity define two compartments of the CD1b-glycolipid-specific T Cell repertoire.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Lipid antigens in immunity.Biological chemistry · 2014Review
- A conserved human T cell population targets mycobacterial antigens presented by CD1b.Nature immunology · 2013Article
- CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens.The Journal of experimental medicine · 2013Article
- Immunological cells and functions in Gaucher disease.Critical reviews in oncogenesis · 2013Review
- Molecular requirements for T cell recognition of N-myristoylated peptides derived from the simian immunodeficiency virus Nef protein.Journal of virology · 2013Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The T cell antigen receptor (TCR) mediates recognition of peptide antigens bound in the groove of major histocompatibility complex (MHC) molecules. This dual recognition is mediated by the complementarity-determining residue (CDR) loops of the alpha and beta chains of a single TCR which contact exposed residues of the peptide antigen and amino acids along the MHC alpha helices. The recent description of T cells that recognize hydrophobic microbial lipid antigens has challenged immunologists to explain, in molecular terms, the nature of this interaction. Structural studies on the murine CD1d1 molecule revealed an electrostatically neutral putative antigen-binding groove beneath the CD1 alpha helices. Here, we demonstrate that alpha/beta TCRs, when transferred into TCR-deficient recipient cells, confer specificity for both the foreign lipid antigen and CD1 isoform. Sequence analysis of a panel of CD1-restricted, lipid-specific TCRs reveals the incorporation of template-independent N nucleotides that encode diverse sequences and frequent charged basic residues at the V(D)J junctions. These sequences permit a model for recognition in which the TCR CDR3 loops containing charged residues project between the CD1 alpha helices, contacting the lipid antigen hydrophilic head moieties as well as adjacent CD1 residues in a manner that explains antigen specificity and CD1 restriction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.