ArticleThe Journal of experimental medicine1999
Activated Ras signals developmental progression of recombinase-activating gene (RAG)-deficient pro-B lymphocytes.
Article in The Journal of experimental medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 82 citations in OpenAlex.
- Pathway incompatibility between NF-κB and RAS signaling constrains oncogenicity in B-cell leukemia.The Journal of biological chemistry · 2026Article
- A novel transgenic mouse strain expressing PKCβII demonstrates expansion of B1 and marginal zone B cell populations.Scientific reports · 2020Article
- It Takes Three Receptors to Raise a B Cell.Trends in immunology · 2020Review
- Uncovering the Role of RNA-Binding Protein hnRNP K in B-Cell Lymphomas.Journal of the National Cancer Institute · 2020Article
- Transcription factor Phf19 positively regulates germinal center reactions that underlies its role in rheumatoid arthritis.American journal of translational research · 2018Article
- Tumorigenesis promotes Mdm4-S overexpression.Oncotarget · 2017Article
- Kras Is Critical for B Cell Lymphopoiesis.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation.The Journal of experimental medicine · 2015Article
- Activation of Ras overcomes B-cell tolerance to promote differentiation of autoreactive B cells and production of autoantibodies.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling.Nature reviews. Immunology · 2014Review
- New insights into pre-BCR and BCR signalling with relevance to B cell malignancies.Nature reviews. Immunology · 2013Review
- Antigen and cytokine receptor signals guide the development of the naïve mature B cell repertoire.Immunologic research · 2013Review
- Lymphocyte development: integration of DNA damage response signaling.Advances in immunology · 2012Review
- Article
- The C104R mutant impairs the function of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) through haploinsufficiency.The Journal of allergy and clinical immunology · 2010Article
- Ras activation of Erk restores impaired tonic BCR signaling and rescues immature B cell differentiation.The Journal of experimental medicine · 2010Article
- The adaptor protein Shc plays a key role during early B cell development.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development.Nature immunology · 2009Article
- Article
- Extracellular signal-regulated protein kinase 2 is required for efficient generation of B cells bearing antigen-specific immunoglobulin G.Molecular and cellular biology · 2007Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
To elucidate the intracellular pathways that mediate early B cell development, we directed expression of activated Ras to the B cell lineage in the context of the recombination-activating gene 1 (RAG1)-deficient background (referred to as Ras-RAG). Similar to the effects of an immunoglobulin (Ig) mu heavy chain (HC) transgene, activated Ras caused progression of RAG1-deficient progenitor (pro)-B cells to cells that shared many characteristics with precursor (pre)-B cells, including downregulation of surface CD43 expression plus expression of lambda5, RAG2, and germline kappa locus transcripts. However, these Ras-RAG pre-B cells also upregulated surface markers characteristic of more mature B cell stages and populated peripheral lymphoid tissues, with an overall phenotype reminiscent of B lineage cells generated in a RAG- deficient background as a result of expression of an Ig mu HC together with a Bcl-2 transgene. Taken together, these findings suggest that activated Ras signaling in pro-B cells induces developmental progression by activating both differentiation and survival signals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.