ArticleThe Journal of experimental medicine1999
Immune adherence-mediated opsonophagocytosis: the mechanism of Leishmania infection.
Article in The Journal of experimental medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 60 citations in OpenAlex.
- Ex Vivo Analysis of the Association of GFP-ExpressingMicroorganisms · 2024Article
- Cross-reactive, natural IgG recognizing L. major promote parasite internalization by dendritic cells and promote protective immunity.Journal of molecular medicine (Berlin, Germany) · 2022Article
- The Paradox of a Phagosomal Lifestyle: How Innate Host Cell-Frontiers in immunology · 2021Review
- Clinical Proteomics Profiling for Biomarker Identification Among Patients Suffering With Indian Post Kala Azar Dermal Leishmaniasis.Frontiers in cellular and infection microbiology · 2020Article
- Role of Metallic Nanoparticles in Vaccinology: Implications for Infectious Disease Vaccine Development.Frontiers in immunology · 2017Review
- Red blood cell complement receptor one level varies with Knops blood group, α(+)thalassaemia and age among Kenyan children.Genes and immunity · 2016Article
- Leishmania major inhibits IL-12 in macrophages by signalling through CR3 (CD11b/CD18) and down-regulation of ETS-mediated transcription.Parasite immunology · 2013Article
- The roles of complement receptor 3 and Fcγ receptors during Leishmania phagosome maturation.Journal of leukocyte biology · 2013Article
- Differential surface deposition of complement proteins on logarithmic and stationary phase Leishmania chagasi promastigotes.The Journal of parasitology · 2012Article
- Dendritic cells in Leishmania major infections: mechanisms of parasite uptake, cell activation and evidence for physiological relevance.Medical microbiology and immunology · 2012Review
- Article
- Macrophages and neutrophils cooperate in immune responses to Leishmania infection.Cellular and molecular life sciences : CMLS · 2011Review
- Kinetic analysis of ex vivo human blood infection by Leishmania.PLoS neglected tropical diseases · 2010Article
- Complement receptor 3 deficiency influences lesion progression during Leishmania major infection in BALB/c mice.Infection and immunity · 2009Article
- Transcriptional inhibition of interleukin-12 promoter activity in Leishmania spp.-infected macrophages.The Journal of parasitology · 2008Article
- Article
- Uptake of Leishmania major by dendritic cells is mediated by Fcgamma receptors and facilitates acquisition of protective immunity.The Journal of experimental medicine · 2006Article
- Zinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro study.BMC infectious diseases · 2004Article
- Polarized expression of Tamm-Horsfall protein by renal tubular epithelial cells activates human granulocytes.Infection and immunity · 2002Article
- Complement interaction with trypanosomatid promastigotes in normal human serum.The Journal of experimental medicine · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To mimic the sandfly pool feeding process and characterize the cellular and biochemical events that occur during the early stages of promastigote-host interaction, we developed an ex vivo model of human blood infection with Leishmania promastigotes. Within 30 s of blood contact, Leishmania promastigotes bind natural anti-Leishmania antibodies, which then activate the classical complement pathway and opsonization by the third component of complement. The opsonized promastigotes undergo an immune adherence reaction and bind quantitatively to erythrocyte CR1 receptors; opsonized Leishmania amastigotes also bind to erythrocytes. Progression of infection implies promastigote transfer from erythrocytes to acceptor blood leukocytes. After 10 min of ex vivo infection, 25% of all leukocytes contain intracellular parasites, indicating that blood cells are the early targets for the invading promastigotes. We propose that adaptation to the immune adherence mechanism aids Leishmania survival, promoting rapid promastigote phagocytosis by leukocytes. This facilitates host colonization and may represent the parasite's earliest survival strategy. In light of this mechanism, it is unlikely that infection-blocking vaccines can be developed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.