ArticleThe Journal of experimental medicine1999
A T cell receptor-specific blockade of positive selection.
Article in The Journal of experimental medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- TCR-like antibodies targeting autoantigen-mhc complexes: a mini-review.Frontiers in immunology · 2022Review
- Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment.Nature communications · 2016Article
- Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection.The Journal of experimental medicine · 2010Article
- Functional development of the T cell receptor for antigen.Progress in molecular biology and translational science · 2010Article
- An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a.Nature immunology · 2009Article
- Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturation.Immunity · 2008Article
- CD80 cytoplasmic domain controls localization of CD28, CTLA-4, and protein kinase Ctheta in the immunological synapse.Journal of immunology (Baltimore, Md. : 1950) · 2005Article
- Antigen presentation: lysoyme, autoimmune diabetes, and Listeria--what do they have in common?Immunologic research · 2005Review
- Altered positive selection due to corecognition of floppy peptide/MHC II conformers supports an integrative model of thymic selection.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Paradoxical intrathymic positive selection in mice with only a covalently presented agonist peptide.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Diversity of T cell repertoire shaped by a single peptide ligand is critically affected by its amino acid residue at a T cell receptor contact.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Visualization of myelin basic protein (MBP) T cell epitopes in multiple sclerosis lesions using a monoclonal antibody specific for the human histocompatibility leukocyte antigen (HLA)-DR2-MBP 85-99 complex.The Journal of experimental medicine · 2000Article
- Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
To investigate the influence of endogenous peptides on the developmental processes that occur during thymocyte selection, we have used monoclonal antibodies that preferentially recognize the major histocompatibility complex (MHC) molecule I-Ek when it is bound to the moth cytochrome c peptide (88-103). One of these antibodies (G35) specifically blocks the positive selection of transgenic thymocytes expressing a T cell receptor that is reactive to this peptide- MHC complex. Furthermore, G35 does not block the differentiation of transgenic T cells bearing receptors for a different I-Ek-peptide complex. This antibody recognizes a subset of endogenous I-Ek-peptide complexes found on a significant fraction of thymic antigen-presenting cells, including cortical and medullary epithelial cells. The sensitivity of G35 to minor alterations in peptide sequence suggests that the thymic peptide-MHC complexes that mediate the positive selection of a particular class II MHC-restricted thymocyte are structurally related to the complexes that can activate it in the periphery.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.