ArticleJournal of neuro-oncology1998
Expression of multidrug resistance protein gene in patients with glioma after chemotherapy.
Article in Journal of neuro-oncology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 92 citations in OpenAlex.
- Revisiting strategies to target ABC transporter-mediated drug resistance in CNS cancer.Cancer biology & medicine · 2025Review
- Progress of nanoparticle drug delivery system for the treatment of glioma.Frontiers in bioengineering and biotechnology · 2024Review
- P-glycoprotein and cancer: what do we currently know?Heliyon · 2022Review
- Doramectin inhibits glioblastoma cell survival via regulation of autophagyInternational journal of oncology · 2022Article
- The effect of thermal therapy on the blood-brain barrier and blood-tumor barrier.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2020Review
- ABC transporters and the hallmarks of cancer: roles in cancer aggressiveness beyond multidrug resistance.Cancer biology & medicine · 2020Review
- Targeting CD133 improves chemotherapeutic efficacy of recurrent pediatric pilocytic astrocytoma following prolonged chemotherapy.Molecular cancer · 2017Article
- CD133 and DNA-PK regulate MDR1 via the PI3K- or Akt-NF-κB pathway in multidrug-resistant glioblastoma cells in vitro.Oncogene · 2016Article
- Temozolomide reverses doxorubicin resistance by inhibiting P-glycoprotein in malignant glioma cells.Journal of neuro-oncology · 2016Article
- Dual-targeting of aberrant glucose metabolism in glioblastoma.Journal of experimental & clinical cancer research : CR · 2015Article
- Epigenetic regulation of miRNA-211 by MMP-9 governs glioma cell apoptosis, chemosensitivity and radiosensitivity.Oncotarget · 2012Article
- Combined use of anticancer drugs and an inhibitor of multiple drug resistance-associated protein-1 increases sensitivity and decreases survival of glioblastoma multiforme cells in vitro.Neurochemical research · 2011Article
- Influence of glioma's multidrug resistance phenotype on (99m)Tc-tetrofosmin uptake.Molecular imaging and biology · 2011Article
- Chemoresistance in gliomas.Molecular and cellular biochemistry · 2008Review
- Quantitative PCR analysis of the expression profile of genes related to multiple drug resistance in tumors of the central nervous system.Journal of neuro-oncology · 2007Article
- Portrait of multifaceted transporter, the multidrug resistance-associated protein 1 (MRP1/ABCC1).Pflugers Archiv : European journal of physiology · 2007Review
- Expression of drug resistance proteins Pgp, MRP1, MRP3, MRP5 and GST-pi in human glioma.Journal of neuro-oncology · 2005Article
- Multidrug resistance-associated protein MRP1 expression in human gliomas: chemosensitization to vincristine and etoposide by indomethacin in human glioma cell lines overexpressing MRP1.Journal of neuro-oncology · 2004Article
- P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells.Brain pathology (Zurich, Switzerland) · 2003Article
- BR96-DOX immunoconjugate targeting of chemotherapy in brain tumor models.Journal of neuro-oncology · 2003Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two different ATP-binding membrane glycoproteins, the 170 kDa P-glycoprotein (P-gp) and the 190 kDa multidrug resistance protein (MRP), are involved in the acquisition of multidrug resistance phenotypes in cancer cells. Overexpression of P-gp is often observed in various human tumors when treated with anticancer agents. In this study, we asked whether MRP was overexpressed in human gliomas after cancer chemotherapy. We investigated expression of MRP and P-gp before and after chemotherapy in tumor samples from patients with glioma. MRP expression was observed in 16 (70%) of 23 untreated patients, and the proportion of MRP-positive cells in the whole cell population ranged from 3 to 32% in the 16 MRP-positive patients. P-gp-positive tumors were observed in 4 (18%) of 23 patients, and the proportional rates of P-gp-positive cells in the whole cell population ranged from 4 to 23%. The proportional rate of MRP-positive or P-gp-positive glioma cells increased after chemotherapy when compared with that before chemotherapy in all patients examined. We could observe no statistically significant correlation between expression of MRP or P-gp and tumor grade. These results suggest that MRP as well as P-gp may be involved in acquired or intrinsic drug resistance in human glioma.
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