ArticleGenetics1999
Inferring the fitness effects of DNA mutations from polymorphism and divergence data: statistical power to detect directional selection under stationarity and free recombination.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed.
- Dinucleotide preferences underlie apparent codon preference reversals in theProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Evolution under a model of functionally buffered deleterious mutations can lead to positive selection in protein-coding genes.Evolution; international journal of organic evolution · 2023Article
- Next-generation development and application of codon model in evolution.Frontiers in genetics · 2023Review
- impMKT: the imputed McDonald and Kreitman test, a straightforward correction that significantly increases the evidence of positive selection of the McDonald and Kreitman test at the gene level.G3 (Bethesda, Md.) · 2022Review
- Functional Divergence of the bag-of-marbles Gene in the Drosophila melanogaster Species Group.Molecular biology and evolution · 2022Article
- Genetic Differentiation and Demographic Trajectory of the Insular Formosan and Orii's Flying Foxes.The Journal of heredity · 2021Article
- Article
- Recent and Long-Term Selection Across Synonymous Sites in Drosophila ananassae.Journal of molecular evolution · 2016Article
- Effects of the population pedigree on genetic signatures of historical demographic events.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Cross-species outlier detection reveals different evolutionary pressures between sister species.The New phytologist · 2014Article
- Evidence for the biogenesis of more than 1,000 novel human microRNAs.Genome biology · 2014Article
- Stabilizing selection, purifying selection, and mutational bias in finite populations.Genetics · 2013Article
- Identifying Darwinian selection acting on different human APOL1 variants among diverse African populations.American journal of human genetics · 2013Article
- Major role of positive selection in the evolution of conservative segments of Drosophila proteins.Proceedings. Biological sciences · 2012Article
- Weak selection and protein evolution.Genetics · 2012Review
- Predicting functionally important SNP classes based on negative selection.BMC bioinformatics · 2011Article
- Selection for translation efficiency on synonymous polymorphisms in recent human evolution.Genome biology and evolution · 2011Article
- Mutational dynamics of murine angiogenin duplicates.BMC evolutionary biology · 2010Article
- Genome wide analyses reveal little evidence for adaptive evolution in many plant species.Molecular biology and evolution · 2010Article
- Estimating the parameters of selection on nonsynonymous mutations in Drosophila pseudoobscura and D. miranda.Genetics · 2010Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fitness effects of classes of DNA mutations can be inferred from patterns of nucleotide variation. A number of studies have attributed differences in levels of polymorphism and divergence between silent and replacement mutations to the action of natural selection. Here, I investigate the statistical power to detect directional selection through contrasts of DNA variation among functional categories of mutations. A variety of statistical approaches are applied to DNA data simulated under Sawyer and Hartl's Poisson random field model. Under assumptions of free recombination and stationarity, comparisons that include both the frequency distributions of mutations segregating within populations and the numbers of mutations fixed between populations have substantial power to detect even very weak selection. Frequency distribution and divergence tests are applied to silent and replacement mutations among five alleles of each of eight Drosophila simulans genes. Putatively "preferred" silent mutations segregate at higher frequencies and are more often fixed between species than "unpreferred" silent changes, suggesting fitness differences among synonymous codons. Amino acid changes tend to be either rare polymorphisms or fixed differences, consistent with a combination of deleterious and adaptive protein evolution. In these data, a substantial fraction of both silent and replacement DNA mutations appear to affect fitness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.