ArticleGenetics1999
The dominant temperature-sensitive lethal DTS7 of Drosophila melanogaster encodes an altered 20S proteasome beta-type subunit.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Selection, counterselection, and conditional gene expression for genetic biocontrol of insects.Insect science · 2026Review
- Sequestration to lipid droplets promotes histone availability by preventing turnover of excess histones.Development (Cambridge, England) · 2021Article
- Proteomic mapping of Drosophila transgenic elav.L-GAL4/+ brain as a tool to illuminate neuropathology mechanisms.Scientific reports · 2020Article
- Protein phosphatase 2A interacts with Verthandi/Rad21 to regulate mitosis and organ development in Drosophila.Scientific reports · 2019Article
- Dysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesicles.Nature communications · 2018Article
- TheJournal of cell science · 2017Article
- APC/CDevelopmental cell · 2017Article
- The initiator caspase Dronc is subject of enhanced autophagy upon proteasome impairment in Drosophila.Cell death and differentiation · 2016Article
- Actin Cytoskeletal Organization in Drosophila Germline Ring Canals Depends on Kelch Function in a Cullin-RING E3 Ligase.Genetics · 2015Article
- Linking aβ42-induced hyperexcitability to neurodegeneration, learning and motor deficits, and a shorter lifespan in an Alzheimer's model.PLoS genetics · 2015Article
- Drosophila Valosin-Containing Protein is required for dendrite pruning through a regulatory role in mRNA metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The role of ubiquitin-mediated pathways in regulating synaptic development, axonal degeneration and regeneration: insights from fly and worm.The Journal of physiology · 2013Review
- Degradation of functional triose phosphate isomerase protein underlies sugarkill pathology.Genetics · 2008Article
- Proteasome function is required to maintain muscle cellular architecture.Biology of the cell · 2007Article
- The ubiquitin-proteasome system postsynaptically regulates glutamatergic synaptic function.Molecular and cellular neurosciences · 2007Article
- Article
- Identification and characterization of a Drosophila proteasome regulatory network.Molecular and cellular biology · 2005Article
- Genetic modifiers of tauopathy in Drosophila.Genetics · 2003Article
- Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila.BMC genetics · 2003Article
- Article
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2 authors.
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Abstract
Proteasomes are multicatalytic complexes that function as the major proteolytic machinery in regulated protein degradation. The eukaryotic 20S proteasome proteolytic core structure comprises 14 different subunits: 7 alpha-type and 7 beta-type. DTS7 is a dominant temperature-sensitive (DTS) lethal mutation at 29 degrees that also acts as a recessive lethal at ambient temperatures. DTS7 maps to cytological position 71AB. Molecular characterization of DTS7 reveals that this is caused by a missense mutation in a beta-type subunit gene, beta2. A previously characterized DTS mutant, l(3)73Ai1, results from a missense mutation in another beta-type subunit gene, beta6. These two mutants share a very similar phenotype, show a strong allele-specific genetic interaction, and are rescued by the same extragenic suppressor, Su(DTS)-1. We propose that these mutants might act as "poison subunits," disrupting proteasome function in a dosage-dependent manner, and suggest how they may interact on the basis of the structure of the yeast 20S proteasome.
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