ArticleGenetics1999
Local transposition of a hobo element within the decapentaplegic locus of Drosophila.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- The haplolethality paradox of the wupA gene in Drosophila.PLoS genetics · 2021Article
- Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks.Genetics and molecular biology · 2018Article
- General survey of hAT transposon superfamily with highlight on hobo element in Drosophila.Genetica · 2012Article
- A branching process for the early spread of a transposable element in a diploid population.Journal of mathematical biology · 2008Article
- Post-integration behavior of a Minos transposon in the malaria mosquito Anopheles stephensi.Molecular genetics and genomics : MGG · 2007Article
- Patterns of Hermes transposition in Drosophila melanogaster.Molecular genetics and genomics : MGG · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have efficiently mobilized a phenotypically silent hobo transgene inserted within the cis-regulatory heldout region of the decapentaplegic (dpp) locus in Drosophila melanogaster. The goal of our experiment was to identify germline transmission of a local transposition event within the dpp locus that meets two specific criteria. First, excision of the hobo construct does not generate an adult mutant phenotype, suggesting minimal alteration to the original site of insertion. Second, we required a new insertion of the hobo transgene into the Haploinsufficient region of the locus approximately 25 kb away. Genetic and molecular criteria are used to evaluate candidate germlines. In a pilot study, this local transposition event occurred independently in two individuals. Both of the transposition events appear to be new insertions into the dpp transcription unit. One insertion is between the two protein-coding exons, and the other is in the 3'-untranslated region of exon three. Strains carrying these insertions are valuable new reagents for the analysis of dpp function and molecular evolution. These results further support the use of the hobo system as an important tool in Drosophila genetics.
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Registered trials
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