ArticleGenetics1999
The haplolethal region at the 16F gene cluster of Drosophila melanogaster: structure and function.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- The haplolethality paradox of the wupA gene in Drosophila.PLoS genetics · 2021Article
- Human gene essentiality.Nature reviews. Genetics · 2018Review
- Article
- Beadex function in the motor neurons is essential for female reproduction in Drosophila melanogaster.PloS one · 2014Article
- From mouse to human: evolutionary genomics analysis of human orthologs of essential genes.PLoS genetics · 2013Article
- Genome-wide patterns of natural variation reveal strong selective sweeps and ongoing genomic conflict in Drosophila mauritiana.Genome research · 2013Article
- The generation of chromosomal deletions to provide extensive coverage and subdivision of the Drosophila melanogaster genome.Genome biology · 2012Article
- Transcriptional adaptor ADA3 of Drosophila melanogaster is required for histone modification, position effect variegation, and transcription.Molecular and cellular biology · 2008Article
- The ribosomal protein genes and Minute loci of Drosophila melanogaster.Genome biology · 2007Article
- Transgenic rescue of the mouse t complex haplolethal locus Thl1.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
- Transcription of Drosophila troponin I gene is regulated by two conserved, functionally identical, synergistic elements.Molecular biology of the cell · 2004Article
- Article
- Prodos is a conserved transcriptional regulator that interacts with dTAF(II)16 in Drosophila melanogaster.Molecular and cellular biology · 2001Article
- Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins.Genetics · 2000Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extensive aneuploid analyses had shown the existence of a few haplolethal (HL) regions and one triplolethal region in the genome of Drosophila melanogaster. Since then, only two haplolethals, 22F1-2 and 16F, have been directly linked to identified genes, dpp and wupA, respectively. However, with the possible exception of dpp, the actual bases for this dosage sensitivity remain unknown. We have generated and characterized dominant-lethal mutations and chromosomal rearrangements in 16F and studied them in relation to the genes in the region. This region extends along 100 kb and includes at least 14 genes. The normal HL function depends on the integrity of a critical 4-kb window of mostly noncoding sequences within the wupA transcription unit that encodes the muscle protein troponin I (TNI). All dominant lethals are breakpoints within that window, which prevent the functional expression of TNI and other adjacent genes in the proximal direction. However, independent mutations in these genes result in recessive lethal phenotypes only. We propose that the HL at 16F represents a long-range cis regulatory region that acts upon a number of functionally related genes whose combined haploidy would yield the dominant-lethal effect.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.