ArticleGenetics1999
The Amylase gene cluster on the evolving sex chromosomes of Drosophila miranda.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- The Amylases of Insects.International journal of insect science · 2018Review
- Evolution of sex chromosomes in insects.Annual review of genetics · 2010Review
- Independent origins of new sex-linked chromosomes in the melanica and robusta species groups of Drosophila.BMC evolutionary biology · 2008Article
- Rates and patterns of chromosomal evolution in Drosophila pseudoobscura and D. miranda.Genetics · 2006Article
- Evolutionary history and mode of the amylase multigene family in Drosophila.Journal of molecular evolution · 2003Article
- Protein evolution and codon usage bias on the neo-sex chromosomes of Drosophila miranda.Genetics · 2003Article
- Article
- The degeneration of Y chromosomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2000Review
- Article
- Common mechanisms of Y chromosome evolution.Genetica · 2000Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
On the basis of chromosomal homology, the Amylase gene cluster in Drosophila miranda must be located on the secondary sex chromosome pair, neo-X (X2) and neo-Y, but is autosomally inherited in all other Drosophila species. Genetic evidence indicates no active amylase on the neo-Y chromosome and the X2-chromosomal locus already shows dosage compensation. Several lines of evidence strongly suggest that the Amy gene cluster has been lost already from the evolving neo-Y chromosome. This finding shows that a relatively new neo-Y chromosome can start to lose genes and hence gradually lose homology with the neo-X. The X2-chromosomal Amy1 is intact and Amy2 contains a complete coding sequence, but has a deletion in the 3'-flanking region. Amy3 is structurally eroded and hampered by missing regulatory motifs. Functional analysis of the X2-chromosomal Amy1 and Amy2 regions from D. miranda in transgenic D. melanogaster flies reveals ectopic AMY1 expression. AMY1 shows the same electrophoretic mobility as the single amylase band in D. miranda, while ectopic AMY2 expression is characterized by a different mobility. Therefore, only the Amy1 gene of the resident Amy cluster remains functional and hence Amy1 is the dosage compensated gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.