ArticleClinical & experimental metastasis1998
Proteolysis of extracellular matrix by invadopodia facilitates human breast cancer cell invasion and is mediated by matrix metalloproteinases.
Article in Clinical & experimental metastasis, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed.
- ACTG1 facilitates proliferation and epithelial-mesenchymal transition-mediated metastasis via COL21A1 in gastric cancer.iScience · 2026Article
- Engineered CD147-CAR macrophages for enhanced phagocytosis of cancers.Cancer immunology, immunotherapy : CII · 2024Article
- Molecular mechanism of bone metastasis in breast cancer.Frontiers in oncology · 2024Review
- Expression patterns of cluster of differentiation 147 impact the prognosis of hepatocellular carcinoma.World journal of gastrointestinal oncology · 2023Article
- Small extracellular vesicles promote invadopodia activity in glioblastoma cells in a therapy-dependent manner.Cellular oncology (Dordrecht, Netherlands) · 2023Article
- Breast cancer: molecular mechanisms of underlying resistance and therapeutic approaches.American journal of cancer research · 2022Review
- Non-Coding RNAs in Invadopodia: New Insights Into Cancer Metastasis.Frontiers in oncology · 2021Review
- Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma.Nature communications · 2020Article
- Invadopodia: clearing the way for cancer cell invasion.Annals of translational medicine · 2020Review
- Nck adapter proteins promote podosome biogenesis facilitating extracellular matrix degradation and cancer invasion.Cancer medicine · 2019Article
- Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan.Frontiers in oncology · 2019Review
- Inhibition of Radiation and Temozolomide-Induced Invadopodia Activity in Glioma Cells Using FDA-Approved Drugs.Translational oncology · 2018Article
- Analysis of Invadopodia Formation in Breast Cancer Cells.Methods in molecular biology (Clifton, N.J.) · 2016Article
- The Association of Serum IL-33 and sST2 with Breast Cancer.Disease markers · 2015Article
- Metastasis review: from bench to bedside.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Review
- Loss of histone H4K20 trimethylation predicts poor prognosis in breast cancer and is associated with invasive activity.Breast cancer research : BCR · 2014Article
- ARF1 regulates the Rho/MLC pathway to control EGF-dependent breast cancer cell invasion.Molecular biology of the cell · 2014Article
- Decreased expression of ADAMTS-1 in human breast tumors stimulates migration and invasion.Molecular cancer · 2013Article
- Mechanobiology of tumor invasion: engineering meets oncology.Critical reviews in oncology/hematology · 2012Review
- Diverse roles for the paxillin family of proteins in cancer.Genes & cancer · 2012Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Breast cancer cell lines vary in invasive behavior and one highly invasive cell line (MDA-MB-231) proteolytically degrades extracellular matrix with invadopodia (Thompson et al. 1992, J Cell Physiol, 150, 534-44; Chen et al 1994, Breast Cancer Res Treat, 31, 217-26). Invadopodial proteolysis of extracellular matrix is thought to be necessary for invasion; however, this has not been demonstrated directly. To obtain such evidence, normal (HBL-100) and malignant (MCF-7, MDA-MB-231) breast cells were evaluated for invadopodial proteolysis of extracellular matrix and invasive behavior. We report that invadopodial proteolysis of immobilized fibronectin is positively correlated with invasion of cells into type I collagen gels. Moreover, reducing the proteolytic activity of invadopodia with the metalloproteinase inhibitor, batimastat (BB-94), also decreases invasion indicating that breast cancer cell invasion is dependent upon proteolytically active invadopodia.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.