ArticleAnalytical chemistry1998
Low-frequency modulation sensors using nanosecond fluorophores.
Article in Analytical chemistry, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 64 citations in OpenAlex.
- Luminescence Lifetime-Based Sensing of Water Turbidity.ACS sensors · 2025Article
- Synthesis and photophysical and electrochemical properties of functionalized mono-, bis-, and trisanthracenyl bridged Ru(II) bis(2,2':6',2"-terpyridine) charge transfer complexes.TheScientificWorldJournal · 2014Article
- On the Possibility of Glucose Sensing Using Boronic Acid and a Luminescent Ruthenium Metal-Ligand Complex.Journal of fluorescence · 2002Article
- A protein biosensor for lactate.Analytical biochemistry · 2000Article
- Novel fluorescence sensing methods for high throughput screening.Journal of biomolecular screening · 2000Article
- Fluorescence properties of rhodamine 800 in whole blood and plasma.Analytical biochemistry · 2000Article
- Polarization-based sensing of glucose using an oriented reference film.Journal of biomedical optics · 1999Article
- Polarization-Based Sensing with a Self-Referenced Sample.Applied spectroscopy · 1999Article
- Polarization sensing with visual detection.Analytical chemistry · 1999Article
- Anisotropy-based sensing with reference fluorophores.Analytical biochemistry · 1999Article
- Glucose sensor for low-cost lifetime-based sensing using a genetically engineered protein.Analytical biochemistry · 1999Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We describe a new approach to fluorescence sensing based on a mixture of fluorophores, one of which is sensitive to the desired analyte. If a long-lifetime analyte-insensitive fluorophore is mixed with a short-lifetime analyte-sensitive fluorophore, the modulation of the emission at conveniently low frequencies becomes equal to the fractional fluorescence intensity of the sensing fluorophore. Under these conditions, the modulation can be used to determine the analyte concentration. This can be used with any fluorophore that changes intensity in response to analyte and does not require the sensing fluorophore to display a change in lifetime. The feasibility of modulation-based sensing was demonstrated using mixtures of 6-carboxyfluorescein and [Ru 2,2'-(bipyridyl)3]2+ as a pH sensor and of the calcium probe Fluo-3 and [Ru 2,2'-(bipyridyl)3]2+ as a calcium sensor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.