Evidence map›Paper›PMID 9868844›Full record

ReviewBulletin of the World Health Organization1998

Epidemiology of rotavirus diarrhoea in Africa: a review to assess the need for rotavirus immunization.

N A Cunliffe, P E Kilgore, J S Bresee, A D Steele, N Luo, C A Hart, R I Glass

Registry-linked trialOpen access · greenAbstract readComparative StudyReview
PubMed Full text at PMC
In one paragraph

Review in Bulletin of the World Health Organization, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03150927 (A Clinical Study to Determine the Effects of a Novel Probiotic Microbial Composite™ on Improving Digestive Health and Key Growth Parameters in Undernourished Young Children), which is not on this map. Cited by 67 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 7 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03150927 naunknown statusnot on this mapstarted 2017, after this paper: background citation

A Clinical Study to Determine the Effects of a Novel Probiotic Microbial Composite™ on Improving Digestive Health and Key Growth Parameters in Undernourished Young Children

TypeinterventionalSponsorBiowish Technologies, Inc.Ran2017 to 2019Enrolled250ConditionsQuality of Life, Malnutrition, Growth ArrestArmsProbiotic Microbial Composite, Placebo
3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 7 syntheses or guidelines pooled it, 244 citations in OpenAlex.

  1. Pooled it
  2. Efficacy ofWorld journal of gastroenterology · 2019
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Probiotics for treating acute infectious diarrhoea.The Cochrane database of systematic reviews · 2010
    Pooled it
  7. Pooled it
  8. Trial
  9. Trial
  10. Trial
  11. Article
  12. Article
  13. Article
  14. Article
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  16. Article
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  18. Article
  19. Article
  20. Seasonality of Rotavirus Hospitalizations at Costa Rica's National Children's Hospital in 2010-2015.International journal of environmental research and public health · 2019
    Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

N A CunliffeViral Gastroenteritis Section, Centers for Disease Control and Prevention, Atlanta, GA, USA.
P E Kilgore
J S Bresee
A D Steele
N Luo
C A Hart
R I Glass
University of Malawi · MWCenters for Disease Control and Prevention · US

Funding

Wellcome Trust
6 · The paper itself

Abstract

Rapid progress towards the development of rotavirus vaccines has prompted a reassessment of the disease burden of rotavirus diarrhoea in developing countries and the possible impact of these vaccines in reducing diarrhoeal morbidity and mortality among infants and young children. We examined the epidemiology and disease burden of rotavirus diarrhoea among hospitalized and clinic patients in African countries through a review of 43 published studies of the etiology of diarrhoea. The studies were carried out from 1975 through 1992, and only those in which a sample of more than 100 patients with diarrhoea were specifically screened for rotavirus by using an established diagnostic test were included. Rotavirus was detected in a median of 24% of children hospitalized for diarrhoea and in 23% who were treated as outpatients; 38% of the hospitalized patients with rotavirus were < 6 months and 81% were < 1 year of age. Rotavirus was detected year-round in nearly every country and generally exhibited distinct seasonal peaks during the dry months. In 5 countries where rotavirus strains had been G-typed, 74% of strains were of one of the four common serotypes (G1 to G4), G1 was the predominant serotype, and 26% were non-typeable. This cumulative experience from 15 African countries suggests that rotavirus is the most important cause of severe diarrhoea in African children and that most strains in circulation today belong to common G types that are included in reassortant vaccines. Wherever large numbers of cases of rotavirus diarrhoea occur early in infancy, immunization at birth may protect the children before their first symptomatic infection.

Indexed as

AfricaAfrica, NorthernAfrica, SouthernAfrica South of the SaharaChildChild, PreschoolDiarrhea, InfantileGastroenteritisHumansImmunizationInfantInfant, NewbornRotavirusRotavirus InfectionsSeasonsSerotypingViral Vaccines

Identifiers

PMID9868844
PMCPMC2305791
OpenAlexW1797104314

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.