ArticleAmerican journal of human genetics1998
Detecting marker-disease association by testing for Hardy-Weinberg disequilibrium at a marker locus.
Article in American journal of human genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers, 1 of them a synthesis that pooled it.
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Who cites it
144 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese.PloS one · 2011Pooled it
- Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan.Human genetics · 2013Trial
- Fetal hemoglobin in sickle cell anemia: genetic determinants of response to hydroxyurea.The pharmacogenomics journal · 2007Trial
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- Integrated analysis of UGT1A1 promoter polymorphism, gene expression, and IL-1β reveals genotype-driven susceptibility in Gilbert syndrome.Molecular biology reports · 2026Article
- Evaluating genetic-based disease prediction approaches through simulation.Human genetics · 2026Article
- Gene-based Hardy-Weinberg equilibrium test using genotype count data: application to six types of cancers.BMC genomics · 2025Article
- Recent Advances in Conductive Polymers-Based Electrochemical Sensors for Biomedical and Environmental Applications.Polymers · 2024Review
- Maternal Age at Menarche Genes Determines Fetal Growth Restriction Risk.International journal of molecular sciences · 2024Article
- The Interaction BetweenFrontiers in psychiatry · 2022Article
- Effect of AMPK Subunit Alpha 2 Polymorphisms on Postherpetic Pain Susceptibility in Southwestern Han Chinese.Journal of pain research · 2022Article
- Quantitative Trait Loci Identification by Estimating the Genetic Model based on the Extremal Samples.Current genomics · 2021Review
- Robust, flexible, and scalable tests for Hardy-Weinberg equilibrium across diverse ancestries.Genetics · 2021Article
- Endometriosis Is Associated with Functional Polymorphism in the Promoter of Heme Oxygenase 1 (Cells · 2021Article
- Evaluation of Polymorphisms in Toll-Like Receptor Genes as Biomarkers of the Response to Treatment of Erythema Nodosum Leprosum.Frontiers in medicine · 2021Article
- A Replication Study Identified Seven SNPs Associated with Quantitative Traits of Type 2 Diabetes among Chinese Population in A Cross-Sectional Study.International journal of environmental research and public health · 2020Article
- APOE region molecular signatures of Alzheimer's disease across races/ethnicities.Neurobiology of aging · 2020Article
- Haplotype architecture of the Alzheimer's risk in theAlzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Genetic predisposition to type 2 diabetes is associated with severity of coronary artery disease in patients with acute coronary syndromes.Cardiovascular diabetology · 2019Observational
84 more citing papers are in PubMed but not listed here.
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Abstract
We review and extend a recent suggestion that fine-scale localization of a disease-susceptibility locus for a complex disease be done on the basis of deviations from Hardy-Weinberg equilibrium among affected individuals. This deviation is driven by linkage disequilibrium between disease and marker loci in the whole population and requires a heterogeneous genetic basis for the disease. A finding of marker-locus Hardy-Weinberg disequilibrium therefore implies disease heterogeneity and marker-disease linkage disequilibrium. Although a lack of departure of Hardy-Weinberg disequilibrium at marker loci implies that disease susceptibilityweighted linkage disequilibria are zero, given disease heterogeneity, it does not follow that the usual measures of linkage disequilibrium are zero. For disease-susceptibility loci with more than two alleles, therefore, care is needed in the drawing of inferences from marker Hardy-Weinberg disequilibria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.