ArticleJournal of bacteriology1999
Identification and properties of the genes encoding microcin E492 and its immunity protein.
Article in Journal of bacteriology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- A reference genome without a virus: cDNA reconstruction reveals the provenance and function of the MS2 phage sequence.bioRxiv : the preprint server for biology · 2026Article
- Antibacterial microcins self-assemble to promote biofilm formation in Acinetobacter baumannii.Cell reports · 2026Article
- Antibacterial action, proteolytic immunity, and in vivo activity of a Vibrio cholerae microcin.Cell host & microbe · 2024Article
- Evidence for Widespread Class II Microcins inApplied and environmental microbiology · 2022Article
- Colicins and Microcins Produced byInternational journal of environmental research and public health · 2022Review
- Structure of the mannose phosphotransferase system (man-PTS) complexed with microcin E492, a pore-forming bacteriocin.Cell discovery · 2021Article
- Microcins inFrontiers in microbiology · 2019Review
- Contact-dependent killing byeLife · 2017Article
- Identification of Key Amino Acid Residues Modulating Intracellular and In vitro Microcin E492 Amyloid Formation.Frontiers in microbiology · 2016Article
- Genotoxic Klebsiella pneumoniae in Taiwan.PloS one · 2014Article
- Microcin e492 amyloid formation is retarded by posttranslational modification.Journal of bacteriology · 2013Article
- Total (bio)synthesis: strategies of nature and of chemists.Topics in current chemistry · 2010Review
- Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds.Natural product reports · 2009Review
- How nature morphs peptide scaffolds into antibiotics.Chembiochem : a European journal of chemical biology · 2009Review
- The production in vivo of microcin E492 with antibacterial activity depends on salmochelin and EntF.Journal of bacteriology · 2008Article
- Polymerizing the fibre between bacteria and host cells: the biogenesis of functional amyloid fibres.Cellular microbiology · 2008Review
- Biosynthetic tailoring of microcin E492m: post-translational modification affords an antibacterial siderophore-peptide conjugate.Journal of the American Chemical Society · 2007Article
- The mannose transporter complex: an open door for the macromolecular invasion of bacteria.Journal of bacteriology · 2006Article
- Bactericidal activity of both secreted and nonsecreted microcin E492 requires the mannose permease.Journal of bacteriology · 2006Article
- Application of comparative phylogenomics to study the evolution of Yersinia enterocolitica and to identify genetic differences relating to pathogenicity.Journal of bacteriology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gene coding for the immunity protein (mceB) and the structural gene of microcin E492 (mceA), a low-molecular-weight channel-forming bacteriocin produced by a strain of Klebsiella pneumoniae, have been characterized. The microcin gene codes for a precursor protein of either 99 or 103 amino acids. Protein sequencing of the N-terminal region of microcin E492 unequivocally identified this gene as the microcin structural gene and indicated that this microcin is synthesized as a precursor protein that is cleaved at either amino acid 15 or 19, at a site resembling the double-glycine motif. The gene encoding the 95-amino-acid immunity protein (mceB) was identified by cloning the DNA segment that encodes only this polypeptide into an expression vector and demonstrating the acquisition of immunity to microcin E492. As expected, the immunity protein was found to be associated with the inner membrane. Analysis of the DNA sequence indicates that these genes belong to the same family as microcin 24, and they do not share structural motifs with any other known channel-forming bacteriocin. The organization of the microcin- and immunity protein-encoding genes suggests that they are coordinately expressed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.