ArticleInfection and immunity1999
Mucin-related epitopes distinguish M cells and enterocytes in rabbit appendix and Peyer's patches.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 52 citations in OpenAlex.
- The Peyer's Patch Mononuclear Phagocyte System at Steady State and during Infection.Frontiers in immunology · 2017Review
- Mimicking microbial strategies for the design of mucus-permeating nanoparticles for oral immunization.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2015Review
- Roles of M cells in infection and mucosal vaccines.Human vaccines & immunotherapeutics · 2014Review
- Mucus properties and goblet cell quantification in mouse, rat and human ileal Peyer's patches.PloS one · 2013Article
- Mucin dynamics and enteric pathogens.Nature reviews. Microbiology · 2011Review
- Mucins in the mucosal barrier to infection.Mucosal immunology · 2008Review
- Immunochemical, biomolecular and biochemical characterization of bovine epithelial intestinal primocultures.BMC cell biology · 2005Article
- Antigen transport into Peyer's patches: increased uptake by constant numbers of M cells.The American journal of pathology · 2004Article
- Vimentin-positive cells in the epithelium of rabbit ileal villi represent cup cells but not M-cells.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2003Article
- Glycocalyx on rabbit intestinal M cells displays carbohydrate epitopes from Muc2.Infection and immunity · 2001Article
- The pathogenesis of Shigella flexneri infection: lessons from in vitro and in vivo studies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2000Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biochemical composition of the apical membranes of epithelial M cells overlying the gut-associated lymphoid tissues (GALT) is still largely unknown. We have prepared monoclonal antibodies (MAbs) directed against carbonate-washed plasma membranes from epithelial cells detached with EDTA from rabbit appendix, a tissue particularly rich in GALT. As determined by immunofluorescence microscopy, several MAbs specifically recognized either M cells or enterocyte-like cells of the domes from rabbit appendix, sacculus rotundus, and Peyer's patches. M cells were identified by their large ventral pocket containing lymphoid cells and by specific labeling with antivimentin. Among various characterized MAbs, MAb 104 recognized rabbit immunoglobulins and was used as an apical marker for M cells in the rabbit appendix, MAb 58 selectively stained an integral membrane glycoprotein of greater than 205 kDa located at the apex of M cells, and MAb 214 stained a smaller soluble glycoprotein associated with the apical surfaces from neighboring enterocytes. In addition, both MAbs 58 and 214 also labeled luminal mucus and secretory granules in goblet cells. The selective association of mucin-related molecules at the surfaces of either M cells or enterocyte-like cells of the follicle-associated epithelium suggests that specific carbohydrate antigens are differentially expressed by epithelial cells and could account for the differential binding properties of pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.