ArticleInfection and immunity1999
Catecholamine oxidative products, but not melanin, are produced by Cryptococcus neoformans during neuropathogenesis in mice.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 72 citations in OpenAlex.
- Melanin deposition in twoThe Journal of biological chemistry · 2020Article
- Two Distinct Approaches for CRISPR-Cas9-Mediated Gene Editing in Cryptococcus neoformans and Related Species.mSphere · 2018Article
- Role of laccase in the virulence of Talaromyces marneffei: A common link between AIDS-related fungal pathogens?Virulence · 2016Article
- Paradoxical Immune Responses in Non-HIV Cryptococcal Meningitis.PLoS pathogens · 2015Article
- Fungal Melanin: What do We Know About Structure?Frontiers in microbiology · 2015Review
- A role for LHC1 in higher order structure and complement binding of the Cryptococcus neoformans capsule.PLoS pathogens · 2014Article
- Laccases involved in 1,8-dihydroxynaphthalene melanin biosynthesis in Aspergillus fumigatus are regulated by developmental factors and copper homeostasis.Eukaryotic cell · 2013Article
- PI3K signaling of autophagy is required for starvation tolerance and virulenceof Cryptococcus neoformans.The Journal of clinical investigation · 2008Article
- Role of a CUF1/CTR4 copper regulatory axis in the virulence of Cryptococcus neoformans.The Journal of clinical investigation · 2007Article
- Cell wall targeting of laccase of Cryptococcus neoformans during infection of mice.Infection and immunity · 2007Article
- Melanization of Cryptococcus neoformans affects lung inflammatory responses during cryptococcal infection.Infection and immunity · 2005Article
- The DEAD-box RNA helicase Vad1 regulates multiple virulence-associated genes in Cryptococcus neoformans.The Journal of clinical investigation · 2005Article
- Urease expression by Cryptococcus neoformans promotes microvascular sequestration, thereby enhancing central nervous system invasion.The American journal of pathology · 2004Article
- CNLAC1 is required for extrapulmonary dissemination of Cryptococcus neoformans but not pulmonary persistence.Infection and immunity · 2004Article
- Laccase of Cryptococcus neoformans is a cell wall-associated virulence factor.Infection and immunity · 2001Article
- Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans.Molecular and cellular biology · 2001Article
- Pathogenic roles for fungal melanins.Clinical microbiology reviews · 2000Review
- Synthesis of polymerized melanin by Cryptococcus neoformans in infected rodents.Infection and immunity · 2000Article
- Laccase protects Cryptococcus neoformans from antifungal activity of alveolar macrophages.Infection and immunity · 1999Article
- Acquisition, transport, and storage of iron by pathogenic fungi.Clinical microbiology reviews · 1999Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Melanin has been proposed as a virulence factor in Cryptococcus neoformans, but its presence has not been shown unambiguously in vivo. Validated methods used previously to show production of cryptococcal eumelanin pigment in vitro (P. R. Williamson, K. Wakamatsu, and S. Ito, J. Bacteriol. 180:1570-1572, 1998) were used to assess for production of laccase-derived products in mouse brain of the Lacc+ strains, 2E-TUC, H99 (serotype A), and ATCC 34873 (serotype D), and the Lacc- strain, 2E-TU. Pyrrole-2,3, 5-tricarboxylic and pyrrole-2,3-dicarboxylic acid, specific degradation products of catecholamine derivatives such as melanin, were found in all Lacc+ strains, but not in the Lacc- strain, 2E-TU. However, the presence of melanin pigment itself could not be demonstrated in the same cells. Lack of the specific degradation products aminohydroxyphenylalanine and aminohydroxyphenylethylamine in Lacc+ strains upon hydriodic acid hydrolysis showed that pheomelanin was also not produced by the fungus in vivo. These are the first data to support the generation of catecholamine oxidation products by C. neoformans in vivo, but they do not support postenzymatic polymerization of these products to form typical eumelanin, as previously proposed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.