ArticleInfection and immunity1999
Effect of melanin and carotenoids of Exophiala (Wangiella) dermatitidis on phagocytosis, oxidative burst, and killing by human neutrophils.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Phaeohyphomycosis in a Solid Organ Transplant Recipient: Case Report of a New Pathogenic Species of Kirschsteiniothelia.Mycopathologia · 2026Article
- A Putative Multicopper Oxidase Encoded byInternational journal of molecular sciences · 2026Article
- Polyextremotolerant, opportunistic, and melanin-driven resilient black yeast Exophiala dermatitidis in environmental and clinical contexts.Scientific reports · 2025Article
- Fungal infections and the fungal microbiome in hepatobiliary disorders.Journal of hepatology · 2023Review
- Phaeohyphomycotic cyst.Autopsy & case reports · 2023Article
- Case report and literature review: double jeopardy -Access microbiology · 2022Article
- Protocol for Genome-Scale Reconstruction and Melanogenesis Analysis ofSTAR protocols · 2020Article
- Microorganisms populating the water-related indoor biome.Applied microbiology and biotechnology · 2020Review
- The Neurotropic Black YeastCells · 2020Article
- Review
- Coccidioidomycosis: Epidemiology, Fungal Pathogenesis, and Therapeutic Development.Current tropical medicine reports · 2019Article
- The Ustilago maydis null mutant strains of the RNA-binding protein UmRrm75 accumulate hydrogen peroxide and melanin.Scientific reports · 2019Article
- Subcutaneous Phaeohyphomycosis: A Clinical Mimic of Skin and Soft Tissue Neoplasms-A Descriptive Study from India.World journal of surgery · 2018Article
- Development of an Improved Carotenoid Extraction Method to Characterize the Carotenoid Composition under Oxidative Stress and Cold Temperature in the Rock Inhabiting FungusJournal of fungi (Basel, Switzerland) · 2018Article
- Exophiala dermatitidis isolates from various sources: using alternative invertebrate host organisms (Caenorhabditis elegans and Galleria mellonella) to determine virulence.Scientific reports · 2018Article
- Transcriptome Study of anFrontiers in microbiology · 2018Article
- Pyomelanin produced by Vibrio cholerae confers resistance to predation by Acanthamoeba castellanii.FEMS microbiology ecology · 2017Article
- Exploring the genomic diversity of black yeasts and relatives (Studies in mycology · 2017Article
- Functions of fungal melanin beyond virulence.Fungal biology reviews · 2017Article
- Comparative proteomic analysis between nitrogen supplemented and starved conditions inProteome science · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The black yeast Exophiala (Wangiella) dermatitidis is an increasingly recognized pathogen and a leading cause of severe pheohyphomycosis. Melanin is thought to contribute to the virulence of E. dermatitidis. Whereas the synthesis and the redox properties of melanin have been studied intensively, the influence of melanin and carotenoids on the phagocytosis, the oxidative burst, and the killing of E. dermatitidis by human neutrophils has not been studied. To study their effects on these phenomena, we applied a combination of flow cytometry and a colony-count-dependent method. Using E. dermatitidis wild-type strain 8565 and several melanin-deficient mutants that have been described previously, we demonstrate that melanin prevents this pathogen from being killed in the phagolysosome of the neutrophils. Melanin did not influence the phagocytosis or the oxidative burst of the neutrophils involved. The carotenoids torulene and torularhodine were not found to contribute to the prevention of killing. The ability of E. dermatitidis to block the effects of the neutrophil oxidative burst may critically impair the potential of the host to sufficiently eliminate this fungal pathogen and thus may play an important role in the pathogenesis of phaeohyphomycosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.