ArticleInfection and immunity1999
Lipopolysaccharide stimulates butyric acid-induced apoptosis in human peripheral blood mononuclear cells.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 83 citations in OpenAlex.
- Microbial metabolites in the pathogenesis of periodontal diseases: a narrative review.Frontiers in oral health · 2023Review
- Evaluation of P53 protein expression in gingival tissues of patients with chronic periodontitis by immunohistochemistry methods.Clinical and experimental dental research · 2022Article
- Modulatory Effect of Papaya Extract against Chlorpyrifos-Induced Oxidative Stress, Immune Suppression, Endocrine Disruption, and DNA Damage in FemaleInternational journal of environmental research and public health · 2022Article
- Silver-Nanoparticle- and Silver-Nitrate-Induced Antioxidant Disbalance, Molecular Damage, and Histochemical Change on the Land Slug (Frontiers in physiology · 2022Article
- Antagonistic effect of different selenium type on green synthesized silver nanoparticle toxicity on Oreochromis niloticus: oxidative stress biomarkers.Environmental science and pollution research international · 2021Article
- Consecutive intra-gingival injections of lipopolysaccharide and butyric acid to mice induce abnormal behavior and changes in cytokine concentrations.Journal of neuroinflammation · 2020Article
- Article
- Antioxidants and molecular damage in Nile Tilapia (Oreochromis niloticus) after exposure to microplastics.Environmental science and pollution research international · 2020Article
- Antioxidant activities of Moringa oleifera leaf extract against pendimethalin-induced oxidative stress and genotoxicity in Nile tilapia, Oreochromis niloticus (L.).Fish physiology and biochemistry · 2019Article
- Butyric acid retention in gingival tissue induces oxidative stress in jugular blood mitochondria.Cell stress & chaperones · 2013Article
- Growth inhibition and apoptosis induction by (+)-Cyanidan-3-ol in hepatocellular carcinoma.PloS one · 2013Article
- Effects of cadmium on some haematological and biochemical characteristics of Oreochromis niloticus (Linnaeus, 1758) dietary supplemented with tomato paste and vitamin E.Fish physiology and biochemistry · 2011Article
- Evaluation of the role of oxidative stress in chemopreventive action of fish oil and celecoxib in the initiation phase of 7,12-dimethyl benz(α)anthracene-induced mammary carcinogenesis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2011Article
- Effects of ultraviolet A on the activity of two metabolic enzymes, DNA damage and lipid peroxidation during early developmental stages of the African catfish, Clarias gariepinus (Burchell, 1822).Fish physiology and biochemistry · 2010Article
- Expression of caspase-3, p53 and Bcl-2 in generalized aggressive periodontitis.Head & face medicine · 2006Article
- The biochemical and morphological alterations following administration of melatonin, retinoic acid and Nigella sativa in mammary carcinoma: an animal model.International journal of experimental pathology · 2005Article
- Transient elevation of interleukin-16 levels at the initial stage of meningitis in children.Clinical and experimental immunology · 2003Article
- Human gingival fibroblasts rescue butyric acid-induced T-cell apoptosis.Infection and immunity · 2002Article
- Butyric acid-induced T-cell apoptosis is mediated by caspase-8 and -9 activation in a Fas-independent manner.Clinical and diagnostic laboratory immunology · 2001Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously reported that butyric acid, an extracellular metabolite from periodontopathic bacteria, induced apoptosis in murine thymocytes, splenic T cells, and human Jurkat T cells. In this study, we examined the ability of butyric acid to induce apoptosis in peripheral blood mononuclear cells (PBMC) and the effect of bacterial lipopolysaccharide (LPS) on this apoptosis. Butyric acid significantly inhibited the anti-CD3 monoclonal antibody- and concanavalin A-induced proliferative responses in a dose-dependent fashion. This inhibition of PBMC growth by butyric acid depended on apoptosis in vitro. It was characterized by internucleosomal DNA digestion and revealed by gel electrophoresis followed by a colorimetric DNA fragmentation assay to occur in a concentration-dependent fashion. Butyric acid-induced PBMC apoptosis was accompanied by caspase-3 protease activity but not by caspase-1 protease activity. LPS potentiated butyric acid-induced PBMC apoptosis in a dose-dependent manner. Flow-cytometric analysis revealed that LPS increased the proportion of sub-G1 cells and the number of late-stage apoptotic cells induced by butyric acid. Annexin V binding experiments with fractionated subpopulations of PBMC in flow cytometory revealed that LPS accelerated the butyric acid-induced CD3(+)-T-cell apoptosis followed by similar levels of both CD4(+)- and CD8(+)-T-cell apoptosis. The addition of LPS to PBMC cultures did not cause DNA fragmentation, suggesting that LPS was unable to induce PBMC apoptosis directly. These data suggest that LPS, in combination with butyric acid, potentiates CD3(+) PBMC T-cell apoptosis and plays a role in the apoptotic depletion of CD4(+) and CD8(+) cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.