ArticlePlant molecular biology1998
Molecular characterization of tobacco ribonucleotide reductase RNR1 and RNR2 cDNAs and cell cycle-regulated expression in synchronized plant cells.
Article in Plant molecular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Folates in Plants: Research Advances and Progress in Crop Biofortification.Frontiers in chemistry · 2017Review
- Long-Term Boron-Excess-Induced Alterations of Gene Profiles in Roots of Two Citrus Species Differing in Boron-Tolerance Revealed by cDNA-AFLP.Frontiers in plant science · 2016Article
- Identification and characterization of alternative promoters, transcripts and protein isoforms of zebrafish R2 gene.PloS one · 2011Article
- The levels of male gametic mitochondrial DNA are highly regulated in angiosperms with regard to mitochondrial inheritance.The Plant cell · 2010Article
- Isolation and characterization of a cotton cdh-like gene.Molecular biology reports · 2010Article
- Article
- Ribonucleotide reductase regulation in response to genotoxic stress in Arabidopsis.Plant physiology · 2009Article
- Rice virescent3 and stripe1 encoding the large and small subunits of ribonucleotide reductase are required for chloroplast biogenesis during early leaf development.Plant physiology · 2009Article
- Nucleotide depletion and chloroplast division.Plant signaling & behavior · 2007Article
- Arabidopsis ribonucleotide reductases are critical for cell cycle progression, DNA damage repair, and plant development.The Plant cell · 2006Article
- Article
- ATR regulates a G2-phase cell-cycle checkpoint in Arabidopsis thaliana.The Plant cell · 2004Article
- UV-C response of the ribonucleotide reductase large subunit involves both E2F-mediated gene transcriptional regulation and protein subcellular relocalization in tobacco cells.Nucleic acids research · 2004Article
- The tobacco A-type cyclin, Nicta;CYCA3;2, at the nexus of cell division and differentiation.The Plant cell · 2003Article
- Comparative transcriptional profiling of placenta and endosperm in developing maize kernels in response to water deficit.Plant physiology · 2003Article
- Transcriptome analysis during cell division in plants.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Cell cycle regulation of the tobacco ribonucleotide reductase small subunit gene is mediated by E2F-like elements.The Plant cell · 2000Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eukaryotic ribonucleotide reductase (RNR), the enzyme involved in the synthesis of the deoxyribonucleotides, consists of two R1 and R2 subunits whose activities and gene expression are differentially regulated during the cell cycle and are preferentially induced at the G1/S transition. We have isolated three cDNA clones from a tobacco S phase library, two encoding the large R1 subunit, the first cloned in plants, and one encoding the small R2 subunit. From Southern blot hybridization we deduce that RNR2 is encoded by a single-copy gene whereas RNR1 is encoded by a small multigene family. The level of RNR mRNA is cell-cycle regulated showing a maximum in S phase. In mid-S phase, RNR2 transcripts show a higher maximum level than RNR1 transcripts. Analysis of the effects of various cell cycle inhibitors added to freshly subcultured stationary phase cells leads to the conclusion that RNR gene induction at the entry of the cells into the cell cycle takes place in late G1-early S phase. Addition of DNA synthesis-blocking agents to cycling cells synchronized in mid-S phase resulted in an enhancement of RNR transcript level, thus suggesting that RNR gene expression may be linked to the DNA synthesis rate by a feedback-like regulatory mechanism.
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