ArticleProceedings of the National Academy of Sciences of the United States of America1998
Adenovirus E4orf6 oncoprotein modulates the function of the p53-related protein, p73.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 55 citations in OpenAlex.
- Conditionally Replicative Adenovirus Controlled by the Stabilization System of AU-Rich Elements Containing mRNA.Cancers · 2020Article
- p73-Binding Partners and Their Functional Significance.International journal of proteomics · 2010Article
- Cataloging and organizing p73 interactions in cell cycle arrest and apoptosis.Nucleic acids research · 2008Article
- Viruses - seeking and destroying the tumor program.Oncogene · 2005Review
- Adenovirus E4orf6 targets pp32/LANP to control the fate of ARE-containing mRNAs by perturbing the CRM1-dependent mechanism.The Journal of cell biology · 2005Article
- PCAF is a coactivator for p73-mediated transactivation.Oncogene · 2003Article
- Nuclear export of adenovirus E4orf6 protein is necessary for its ability to antagonize apoptotic activity of BH3-only proteins.Oncogene · 2003Article
- Differential regulation of p63 and p73 expression.Oncogene · 2003Article
- Physical and functional interaction between HCV core protein and the different p73 isoforms.Oncogene · 2003Article
- p53 induces the expression of its antagonist p73 Delta N, establishing an autoregulatory feedback loop.Oncogene · 2002Article
- T antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesis.Microbiology and molecular biology reviews : MMBR · 2002Review
- Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter.Molecular and cellular biology · 2002Article
- Effect of the human cytomegalovirus IE86 protein on expression of E2F-responsive genes: a DNA microarray analysis.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Adenovirus E3-6.7K maintains calcium homeostasis and prevents apoptosis and arachidonic acid release.Journal of virology · 2002Article
- E4orf6 variants with separate abilities to augment adenovirus replication and direct nuclear localization of the E1B 55-kilodalton protein.Journal of virology · 2002Article
- Identification of three functions of the adenovirus e4orf6 protein that mediate p53 degradation by the E4orf6-E1B55K complex.Journal of virology · 2001Article
- Two distinct activities contribute to the oncogenic potential of the adenovirus type 5 E4orf6 protein.Journal of virology · 2000Article
- Article
- HTLV-1 tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration.Oncogene · 2000Article
- Functional impairment of p73 and p51, the p53-related proteins, by the human T-cell leukemia virus type 1 Tax oncoprotein.Oncogene · 2000Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Recently, several proteins have been identified that are related in their sequence to the p53 tumor-suppressor protein. One of these proteins, which is termed p73, exhibits sequence homology to the p53 transcriptional activation, DNA binding, and oligomerization domains. The adenovirus E1B 55-kDa protein, the adenovirus E4orf6 protein, and SV40 T antigen each can bind to p53 and inhibit p53 function. Here we demonstrate that the adenovirus E4orf6 protein, but not the E1B 55-kDa protein or T antigen, interacts with p73. The E4orf6 protein inhibits p73-mediated transcriptional activation and cell killing in a manner similar to its effect on p53. Thus, only a subset of viral oncoproteins that antagonize p53 function also interacts with the related p73 protein.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.