ArticleProceedings of the National Academy of Sciences of the United States of America1998
A genome-wide search for chromosomal loci linked to mental health wellness in relatives at high risk for bipolar affective disorder among the Old Order Amish.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 80 citations in OpenAlex.
- Alternatives in Assessing Mental Healthcare Disparities Using the Behavioral Risk Factor Surveillance System.Health equity · 2018Article
- Symptom profiles and illness course among Anabaptist and Non-Anabaptist adults with major mood disorders.International journal of bipolar disorders · 2016Article
- Commonalities in Development of Pure Breeds and Population Isolates Revealed in the Genome of the Sardinian Fonni's Dog.Genetics · 2016Article
- Disruption of sonic hedgehog signaling in Ellis-van Creveld dwarfism confers protection against bipolar affective disorder.Molecular psychiatry · 2015Article
- Genomic view of bipolar disorder revealed by whole genome sequencing in a genetic isolate.PLoS genetics · 2014Article
- Chromosome 18p11.2 harbors susceptibility marker: D18S452, for bipolar affective disorder.Indian journal of psychiatry · 2013Article
- Amish revisited: next-generation sequencing studies of psychiatric disorders among the Plain people.Trends in genetics : TIG · 2013Review
- A genome-wide linkage study of bipolar disorder and co-morbid migraine: replication of migraine linkage on chromosome 4q24, and suggestion of an overlapping susceptibility region for both disorders on chromosome 20p11.Journal of affective disorders · 2010Article
- Extent and distribution of linkage disequilibrium in the Old Order Amish.Genetic epidemiology · 2010Article
- Association study of clock gene (CLOCK) and schizophrenia and mood disorders in the Japanese population.European archives of psychiatry and clinical neuroscience · 2009Article
- Article
- Common variations in 4p locus are related to male completed suicide.Neuromolecular medicine · 2009Article
- Genetics of bipolar disorder.Dialogues in clinical neuroscience · 2008Review
- Investigations of the Y chromosome, male founder structure and YSTR mutation rates in the Old Order Amish.Human heredity · 2008Article
- Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia.Molecular psychiatry · 2005Article
- Maternal lineages and Alzheimer disease risk in the Old Order Amish.Human genetics · 2005Article
- Genetics of major mood disorders.Psychiatry (Edgmont (Pa. : Township)) · 2004Article
- Evidence for a putative bipolar disorder locus on 2p13-16 and other potential loci on 4q31, 7q34, 8q13, 9q31, 10q21-24, 13q32, 14q21 and 17q11-12.Molecular psychiatry · 2003Article
- Quantitative-trait homozygosity and association mapping and empirical genomewide significance in large, complex pedigrees: fasting serum-insulin level in the Hutterites.American journal of human genetics · 2002Article
- Review of bipolar molecular linkage and association studies.Current psychiatry reports · 2002Review
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Authors and funding
31 authors at 1 institution in 1 country.
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Abstract
Bipolar affective disorder (BPAD; manic-depressive illness) is characterized by episodes of mania and/or hypomania interspersed with periods of depression. Compelling evidence supports a significant genetic component in the susceptibility to develop BPAD. To date, however, linkage studies have attempted only to identify chromosomal loci that cause or increase the risk of developing BPAD. To determine whether there could be protective alleles that prevent or reduce the risk of developing BPAD, similar to what is observed in other genetic disorders, we used mental health wellness (absence of any psychiatric disorder) as the phenotype in our genome-wide linkage scan of several large multigeneration Old Order Amish pedigrees exhibiting an extremely high incidence of BPAD. We have found strong evidence for a locus on chromosome 4p at D4S2949 (maximum GENEHUNTER-PLUS nonparametric linkage score = 4.05, P = 5. 22 x 10(-4); SIBPAL Pempirical value <3 x 10(-5)) and suggestive evidence for a locus on chromosome 4q at D4S397 (maximum GENEHUNTER-PLUS nonparametric linkage score = 3.29, P = 2.57 x 10(-3); SIBPAL Pempirical value <1 x 10(-3)) that are linked to mental health wellness. These findings are consistent with the hypothesis that certain alleles could prevent or modify the clinical manifestations of BPAD and perhaps other related affective disorders.
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