ArticleProceedings of the National Academy of Sciences of the United States of America1998
Comparative studies on mammalian Hoxc8 early enhancer sequence reveal a baleen whale-specific deletion of a cis-acting element.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 64 citations in OpenAlex.
- Conserved Noncoding Elements Evolve Around the Same Genes Throughout Metazoan Evolution.Genome biology and evolution · 2024Article
- Functional analysis of a first hindlimb positioning enhancer viaFrontiers in cell and developmental biology · 2024Article
- Evolution of stickleback spines through independent cis-regulatory changes at HOXDB.Nature ecology & evolution · 2022Article
- Theria-specific homeodomain and cis-regulatory element evolution of the Dlx3-4 bigene cluster in 12 different mammalian species.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2012Article
- Article
- Genetic engineering of a mouse: Dr. Frank Ruddle and somatic cell genetics.The Yale journal of biology and medicine · 2011Review
- Elephant shark (Callorhinchus milii) provides insights into the evolution of Hox gene clusters in gnathostomes.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Genomic regions with distinct genomic distance conservation in vertebrate genomes.BMC genomics · 2009Article
- Functional evolution of the p53 regulatory network through its target response elements.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Enhancer identification through comparative genomics.Seminars in cell & developmental biology · 2007Review
- Functional diversification of sonic hedgehog paralog enhancers identified by phylogenomic reconstruction.Genome biology · 2007Article
- Branching out: the ramosa pathway and the evolution of grass inflorescence morphology.The Plant cell · 2006Article
- An evolutionary constraint: strongly disfavored class of change in DNA sequence during divergence of cis-regulatory modules.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Gene network polymorphism is the raw material of natural selection: the selfish gene network hypothesis.Journal of molecular evolution · 2004Article
- Divergence of Hoxc8 early enhancer parallels diverged axial morphologies between mammals and fishes.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Phylogenetic analysis of the mammalian Hoxc8 non-coding region.Journal of structural and functional genomics · 2003Article
- Molecular evolution of the HoxA cluster in the three major gnathostome lineages.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Analysis of a complete homeobox gene repertoire: implications for the evolution of diversity.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Hox cluster genomics in the horn shark, Heterodontus francisci.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
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5 authors at 1 institution in 1 country.
Funding
Abstract
Variations in regulatory regions of developmental control genes have been implicated in the divergence of axial morphologies. To find potentially significant changes in cis-regulatory regions, we compared nucleotide sequences and activities of mammalian Hoxc8 early enhancers. The nucleotide sequence of the early enhancer region is extremely conserved among mammalian clades, with five previously described cis-acting elements, A-E, being invariant. However, a 4-bp deletion within element C of the Hoxc8 early enhancer sequence is observed in baleen whales. When assayed in transgenic mouse embryos, a baleen whale enhancer (unlike other mammalian enhancers) directs expression of the reporter gene to more posterior regions of the neural tube but fails to direct expression to posterior mesoderm. We suggest that regulation of Hoxc8 in baleen whales differs from other mammalian species and may be associated with variation in axial morphology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.