ArticleProceedings of the National Academy of Sciences of the United States of America1998
Metabolism to a response pathway selective retinoid ligand during axial pattern formation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 24 citations in OpenAlex.
- Retinoids in the Pathogenesis and Treatment of Liver Diseases.Nutrients · 2022Review
- Carotenoid modifying enzymes in metazoans.Methods in enzymology · 2022Article
- Generating Diverse Spinal Motor Neuron Subtypes from Human Pluripotent Stem Cells.Stem cells international · 2016Review
- Synthesis and use of stable isotope enriched retinals in the field of vitamin A.Molecules (Basel, Switzerland) · 2010Review
- Metabolism and regulation of gene expression by 4-oxoretinol versus all-trans retinoic acid in normal human mammary epithelial cells.Journal of cellular physiology · 2009Article
- Metabolism and transactivation activity of 13,14-dihydroretinoic acid.The Journal of biological chemistry · 2005Article
- Active repression of RAR signaling is required for head formation.Genes & development · 2001Article
- Regulation of cytochrome P450 (CYP) genes by nuclear receptors.The Biochemical journal · 2000Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report identification of 9-cis-4-oxo-retinoic acid (9-cis-4-oxo-RA) as an in vivo retinoid metabolite in Xenopus embryos. 9-Cis-4-oxo-RA bound receptors (RARs) alpha, beta, and gamma as well as retinoid X receptors (RXRs) alpha, beta, and gamma in vitro. However, this retinoid displayed differential RXR activation depending on the response pathway used. Although it failed to activate RXRs in RXR homodimers, it activated RXRs and RARs synergistically in RAR-RXR heterodimers. 9-Cis-4-oxo-RA thus acted as a dimer-specific agonist. Considering that RAR-RXR heterodimers are major functional units involved in transducing retinoid signals during embryogenesis and that 9-cis-4-oxo-RA displayed high potency for modulating axial pattern formation in Xenopus, metabolism to 9-cis-4-oxo-RA may provide a mechanism to target retinoid action to this and other RAR-RXR heterodimer-mediated processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.