ArticleProceedings of the National Academy of Sciences of the United States of America1998
Otoconin-90, the mammalian otoconial matrix protein, contains two domains of homology to secretory phospholipase A2.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 129 citations in OpenAlex.
- Gene expression dynamics of human and mouse craniofacial development at the single-cell level.Nature communications · 2026Article
- Serum Otolin-1 and Otoconin-90 are not elevated in vestibular migraine: a preliminary case-control study.Frontiers in neuroscience · 2026Article
- NADPH Oxidase 3: Beyond the Inner Ear.Antioxidants (Basel, Switzerland) · 2024Review
- shox2 is required for vestibular statoacoustic neuron development.Biology open · 2022Article
- Otoconia Structure After Short- and Long-Duration Exposure to Altered Gravity.Journal of the Association for Research in Otolaryngology : JARO · 2021Article
- What do secreted phospholipases ABiochimie · 2021Review
- Molecular Mediators of Estrogen Reduction-induced Otolith Shedding.Current medical science · 2021Article
- Functional cooperation between two otoconial proteins Oc90 and Nox3.Journal of vestibular research : equilibrium & orientation · 2021Article
- Whole genome detection of recent selection signatures in Sarabi cattle: a unique Iranian taurine breed.Genes & genomics · 2020Article
- Zebrafish otolith biomineralization requires polyketide synthase.Mechanisms of development · 2019Article
- Morphology of the utricular otolith organ in the toadfish, Opsanus tau.The Journal of comparative neurology · 2018Article
- Otoconia and otolithic membrane fragments within the posterior semicircular canal in benign paroxysmal positional vertigo.The Laryngoscope · 2017Article
- Spatiotemporal differences in otoconial gene expression.Genesis (New York, N.Y. : 2000) · 2016Article
- A substitution mutation in cardiac ubiquitin ligase, FBXO32, is associated with an autosomal recessive form of dilated cardiomyopathy.BMC medical genetics · 2016Article
- A new era of secreted phospholipase A₂.Journal of lipid research · 2015Article
- Otolith tethering in the zebrafish otic vesicle requires Otogelin and α-Tectorin.Development (Cambridge, England) · 2015Article
- Mechanisms of otoconia and otolith development.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Review
- Effect of Otoconial Proteins Fetuin A, Osteopontin, and Otoconin 90 on the Nucleation and Growth of Calcite.Crystal growth & design · 2015Article
- Identification and characterization of mouse otic sensory lineage genes.Frontiers in cellular neuroscience · 2015Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The ability to sense orientation relative to gravity requires dense particles, called otoconia, which are localized in the vestibular macular organs. In mammals, otoconia are composed of proteins (otoconins) and calcium carbonate crystals in a calcite lattice. Little is known about the mechanisms that regulate otoconial biosynthesis. To begin to elucidate these mechanisms, we have partially sequenced and cloned the major protein component of murine otoconia, otoconin-90 (OC90). The amino acid sequence identified an orphan chimeric human cDNA. Because of its similarity to secretory phospholipase A2 (sPLA2), this gene was referred to as PLA2-like (PLA2L) and enabled the identification of human Oc90. Partial murine cDNA and genomic clones were isolated and shown to be specifically expressed in the developing mouse otocyst. The mature mouse OC90 is composed of 453 residues and contains two domains homologous to sPLA2. The cloning of Oc90 will allow an examination of the role of this protein in otoconial biosynthesis and in diseases that affect the vestibular system.
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